{"id":"W2905400988","doi":"10.3324/haematol.2018.195172","title":"The thymidine dideoxynucleoside analog, alovudine, inhibits the mitochondrial DNA polymerase γ, impairs oxidative phosphorylation and promotes monocytic differentiation in acute myeloid leukemia","year":2018,"lang":"en","type":"article","venue":"Haematologica","topic":"Acute Myeloid Leukemia Research","field":"Medicine","cited_by":30,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; University Health Network","funders":"Canadian Institutes of Health Research; Leukemia and Lymphoma Society","keywords":"Biology; Mitochondrial DNA; Oxidative phosphorylation; Respiratory chain; Mitochondrial respiratory chain; Myeloid leukemia; Mitochondrion; Molecular biology; Polymerase; DNA polymerase; Cellular differentiation; Cell biology; Cancer research; Biochemistry; DNA; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001234502,0.0002075164,0.0001588943,0.0002139883,0.0001305584,0.0002871816,0.0001599449,0.0001583995,0.0006757391],"category_scores_gemma":[0.000123979,0.00009628072,0.0001129794,0.0001579924,0.0001317957,0.0001465961,0.00009001347,0.0004227929,0.0001609066],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002843539,"about_ca_system_score_gemma":0.0002373147,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006005249,"about_ca_topic_score_gemma":0.001596133,"domain_scores_codex":[0.9998897,0.00002289063,0.00001301039,0.00001515235,0.00003798202,0.00002118722],"domain_scores_gemma":[0.9999585,0.000008751499,0.00001024003,0.000005361615,0.00000713288,0.000009998816],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001513661,0.00007226111,0.0003340764,0.00005697814,0.000006425225,0.00003410916,0.00001133322,0.0001158792,0.9921324,0.000309841,0.00007436611,0.006701116],"study_design_scores_gemma":[0.00005748184,0.0005918699,0.00274052,0.000006582201,0.00001749411,0.0001961152,0.00001304715,0.0006373188,0.9885981,0.0001069024,0.007030991,0.000003611219],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9794176,0.01352806,0.004009611,0.0002609807,0.00007760978,0.00006993375,0.0002921453,0.0000771037,0.002266966],"genre_scores_gemma":[0.9922343,0.004036226,0.001850415,0.0000548314,0.00001373144,0.00002311937,0.0002854901,0.000008075685,0.001493629],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0006757391,"threshold_uncertainty_score":0.002260566,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01660425653193214,"score_gpt":0.2778918988496143,"score_spread":0.2612876423176821,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}