{"id":"W2905404834","doi":"10.1002/pro.3562","title":"The p<i>K</i><sub>a</sub> values of the catalytic residues in the retaining glycoside hydrolase T26H mutant of T4 lysozyme","year":2018,"lang":"en","type":"article","venue":"Protein Science","topic":"Glycosylation and Glycoproteins Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canada's Michael Smith Genome Sciences Centre; University of British Columbia","funders":"British Columbia Knowledge Development Fund; Natural Sciences and Engineering Research Council of Canada; Canada Foundation for Innovation","keywords":"Chemistry; Lysozyme; Stereochemistry; Active site; Protonation; Transition state analog; Hydrolase; Population; Deprotonation; Enzyme; Biochemistry; Organic chemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.003226668,0.0001137524,0.0001141706,0.00006741246,0.0004660668,0.00005981497,0.001423299,0.00005936162,0.000002629602],"category_scores_gemma":[0.001843261,0.00005700062,0.00006974534,0.0008817152,0.002447567,0.00001567068,0.0003953315,0.0001558753,0.000006054669],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002095605,"about_ca_system_score_gemma":0.0004082595,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001085009,"about_ca_topic_score_gemma":0.0002632307,"domain_scores_codex":[0.9979625,0.000235494,0.0003245025,0.0003324333,0.000772164,0.0003729564],"domain_scores_gemma":[0.9984756,0.0000651107,0.0001870523,0.000920761,0.0003032469,0.00004822365],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008133239,0.00002542402,0.0008078231,0.00001142023,0.00000427253,0.000001046363,0.000366828,0.00001618854,0.9955526,0.0004436283,0.00003565702,0.002653788],"study_design_scores_gemma":[0.0002003131,0.0002626838,0.003977858,0.00005085591,0.00000352223,0.000008758202,0.0002541588,0.0006005764,0.9928643,0.001079311,0.0006226337,0.00007508098],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9965885,0.0003166332,0.00007616146,0.0007919112,0.00004221226,0.0007306483,0.000005731183,0.000003948133,0.001444208],"genre_scores_gemma":[0.9995709,0.00003355732,0.00008871111,0.00008852987,0.00006375923,0.00006162474,0.000001367904,0.000007849483,0.00008371026],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003170035,"threshold_uncertainty_score":0.9018162,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01374786554695543,"score_gpt":0.2785386944036395,"score_spread":0.264790828856684,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}