{"id":"W2905406133","doi":"10.1186/s13059-018-1589-8","title":"Enhancers in the Peril lincRNA locus regulate distant but not local genes","year":2018,"lang":"en","type":"article","venue":"Genome biology","topic":"Cancer-related molecular mechanisms research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":46,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"National Institute of General Medical Sciences; National Institute of Mental Health; Howard Hughes Medical Institute","keywords":"Biology; Human genetics; Locus (genetics); Genetics; Enhancer; Genome Biology; Gene; Evolutionary biology; Computational biology; Genomics; Genome; Transcription factor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001840387,0.0002414359,0.0001631643,0.0002977758,0.0001772631,0.0003329913,0.0002809292,0.0002517723,0.002120184],"category_scores_gemma":[0.0002937759,0.0001387828,0.0002306211,0.0001223561,0.0003636433,0.0002306213,0.0004868493,0.0005104029,0.0009473392],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003523414,"about_ca_system_score_gemma":0.0001724862,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002597257,"about_ca_topic_score_gemma":0.0008225753,"domain_scores_codex":[0.9997765,0.0000184095,0.00001254339,0.00009136752,0.00006616504,0.00003503018],"domain_scores_gemma":[0.9993925,0.0001233051,0.0002560666,0.00008284479,0.00004999371,0.00009528341],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005692026,0.000009506635,0.001329718,0.0000263069,0.000003206717,0.00004860603,0.00001383391,0.00005729305,0.9968216,0.0001515831,0.00003561853,0.001445802],"study_design_scores_gemma":[0.00002057745,0.0001960153,0.08531621,0.00003253832,0.0000225785,0.0007553673,0.00005217062,0.002438046,0.9050869,0.0002444578,0.005822196,0.00001293867],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9825404,0.00145675,0.01219912,0.0001438214,0.00003199389,0.00001804412,0.0005598183,0.0004560423,0.002593953],"genre_scores_gemma":[0.9912978,0.0002053965,0.004725921,0.00009494311,0.00001664098,0.00002857146,0.0008259983,0.00009336675,0.002711321],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002120184,"threshold_uncertainty_score":0.007092774,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01150408619039653,"score_gpt":0.277768103650994,"score_spread":0.2662640174605974,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}