{"id":"W2905418559","doi":"10.1002/jcph.1349","title":"Population Pharmacokinetic Study and Individual Dose Adjustments of High‐Dose Methotrexate in Chinese Pediatric Patients With Acute Lymphoblastic Leukemia or Osteosarcoma","year":2018,"lang":"en","type":"article","venue":"The Journal of Clinical Pharmacology","topic":"Acute Lymphoblastic Leukemia research","field":"Medicine","cited_by":43,"is_retracted":false,"has_abstract":true,"ca_institutions":"Emergent BioSolutions (Canada)","funders":"Research Grants Council, University Grants Committee","keywords":"NONMEM; Medicine; Pharmacokinetics; Osteosarcoma; Population; Methotrexate; Oncology; Pharmacology; Internal medicine; Cancer research","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001037032,0.0002464663,0.0004883875,0.0002323716,0.0002071978,0.0002423419,0.0002495081,0.0002115912,0.0005188339],"category_scores_gemma":[0.001945135,0.0001717241,0.0005208324,0.0004510083,0.0001524923,0.0001962534,0.0002217921,0.0003194688,0.00006891517],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006569915,"about_ca_system_score_gemma":0.001050654,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.007867731,"about_ca_topic_score_gemma":0.007247052,"domain_scores_codex":[0.9995639,0.0002015376,0.00002769707,0.00009902312,0.00007565796,0.00003230003],"domain_scores_gemma":[0.9995401,0.0001669936,0.0001440101,0.00008162957,0.00004253626,0.00002476263],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.002149985,0.0004449079,0.8813704,0.000141126,0.0006230679,0.0006053312,0.0008377649,0.02966563,0.01538922,0.000655287,0.0006329112,0.06748439],"study_design_scores_gemma":[0.0002050453,0.002494901,0.9023581,0.00001179459,0.0004723245,0.0008047953,0.0002388439,0.0838811,0.006058015,0.000535026,0.002893948,0.00004618632],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.99763,0.00009661395,0.001954928,0.00002639672,0.000001775131,0.00002135483,0.0001063285,0.0000168938,0.0001456749],"genre_scores_gemma":[0.9982997,0.00007103897,0.001226469,0.00001466578,0.000002851405,0.00002762155,0.0002325784,0.000004063329,0.0001211592],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.007867731,"threshold_uncertainty_score":0.01564384,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04220089084212338,"score_gpt":0.4145748417704224,"score_spread":0.3723739509282991,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}