{"id":"W2905430542","doi":"10.1126/science.aav1483","title":"Synaptotagmin-3 drives AMPA receptor endocytosis, depression of synapse strength, and forgetting","year":2018,"lang":"en","type":"article","venue":"Science","topic":"Neuroscience and Neuropharmacology Research","field":"Neuroscience","cited_by":138,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"FP7 Ideas: European Research Council; Deutsche Forschungsgemeinschaft; Canadian Institutes of Health Research; Alexander von Humboldt-Stiftung","keywords":"AMPA receptor; Long-term potentiation; Endocytic cycle; Neuroscience; Long-term depression; Forgetting; Synaptic plasticity; Postsynaptic potential; Silent synapse; Synapse; Metaplasticity; Glutamate receptor; Cell biology; Biology; Chemistry; Endocytosis; Receptor; Psychology; Biochemistry; Cognitive psychology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["sts"],"consensus_categories":[],"category_scores_codex":[0.0006820587,0.000144638,0.0001731346,0.0003196086,0.0008562358,0.00009116004,0.0009717103,0.00003864725,0.00008328618],"category_scores_gemma":[0.002822876,0.0001169721,0.00003248042,0.001431014,0.006584106,0.0007558039,0.0006557933,0.0002133844,0.00004613069],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002104393,"about_ca_system_score_gemma":0.0001807484,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000004269576,"about_ca_topic_score_gemma":0.000001379679,"domain_scores_codex":[0.9972884,0.000156049,0.0002455247,0.000908406,0.0007356782,0.0006659133],"domain_scores_gemma":[0.9986352,0.0005084594,0.0001382654,0.0003531455,0.0001192653,0.0002456457],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002968712,0.00005418356,0.004122815,0.000009423934,4.43372e-7,0.000008959835,0.0002163377,5.707068e-7,0.990967,0.0002390553,0.00008219881,0.004269268],"study_design_scores_gemma":[0.0002267872,0.0003055642,0.004438917,0.00002474767,0.000003224388,0.00004489599,0.0000561124,0.0005917457,0.9932046,0.00008598621,0.0009015053,0.0001159407],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9978711,0.00004530026,0.00002590628,0.000214372,0.0005053632,0.000215408,0.00000942642,0.00005420194,0.001058942],"genre_scores_gemma":[0.9989536,0.0001658818,0.0001721141,0.0004020298,0.00007344908,0.00001145983,6.735355e-8,0.00001017204,0.0002112167],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00572787,"threshold_uncertainty_score":0.9961194,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03278360775437445,"score_gpt":0.3451736060904551,"score_spread":0.3123899983360806,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}