{"id":"W2905430542","doi":"10.1126/science.aav1483","title":"Synaptotagmin-3 drives AMPA receptor endocytosis, depression of synapse strength, and forgetting","year":2018,"lang":"en","type":"article","venue":"Science","topic":"Neuroscience and Neuropharmacology Research","field":"Neuroscience","cited_by":138,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"FP7 Ideas: European Research Council; Deutsche Forschungsgemeinschaft; Canadian Institutes of Health Research; Alexander von Humboldt-Stiftung","keywords":"AMPA receptor; Long-term potentiation; Endocytic cycle; Neuroscience; Long-term depression; Forgetting; Synaptic plasticity; Postsynaptic potential; Silent synapse; Synapse; Metaplasticity; Glutamate receptor; Cell biology; Biology; Chemistry; Endocytosis; Receptor; Psychology; Biochemistry; Cognitive psychology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001222611,0.0005031159,0.0003323884,0.0002936798,0.0001719282,0.0003892018,0.0003858908,0.000397573,0.0007726155],"category_scores_gemma":[0.0002149545,0.0002651175,0.0004901327,0.0002078823,0.0005656484,0.0003064911,0.0004696229,0.001076627,0.0002507652],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005678699,"about_ca_system_score_gemma":0.0003651224,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001164135,"about_ca_topic_score_gemma":0.002480411,"domain_scores_codex":[0.9998066,0.00001171735,0.00002710889,0.00003908441,0.00006738448,0.0000482409],"domain_scores_gemma":[0.9996568,0.00002973014,0.0001576788,0.00003930509,0.00002666655,0.00008982416],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006576264,0.00001017189,0.0002280109,0.00001524228,0.000005994038,0.0000795454,0.000009787252,0.00004392006,0.998958,0.0000933359,0.00001941461,0.000470808],"study_design_scores_gemma":[0.0000191598,0.0001049907,0.006342501,0.00000474574,0.00002062667,0.0003516251,0.00002719106,0.001224046,0.9912093,0.000152155,0.0005370156,0.000006752806],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9968748,0.0004348932,0.001773647,0.00009700393,0.00002639488,0.000006390443,0.0002305194,0.00009791543,0.000458411],"genre_scores_gemma":[0.9970836,0.0003787215,0.0008659139,0.000039197,0.000006759133,0.00001382397,0.0002491788,0.00004319317,0.001319544],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001164135,"threshold_uncertainty_score":0.004120171,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03278360775437445,"score_gpt":0.3451736060904551,"score_spread":0.3123899983360806,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}