{"id":"W2905442284","doi":"10.1182/blood-2018-99-117201","title":"Deep and Durable Responses with Selinexor, Daratumumab, and Dexamethasome (SDd) in Patients with Multiple Myeloma (MM) Previously Exposed to Proteasome Inhibitors and Immunomodulatory Drugs: Results of Phase 1b Study of SDd","year":2018,"lang":"en","type":"article","venue":"Blood","topic":"Multiple Myeloma Research and Treatments","field":"Medicine","cited_by":8,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; Hôpital Maisonneuve-Rosemont; Queen Elizabeth II Health Sciences Centre; Royal Victoria Hospital; Dalhousie University; CancerCare Manitoba; Vancouver General Hospital; University of Calgary","funders":"","keywords":"Tolerability; Medicine; Daratumumab; Internal medicine; Carfilzomib; Neutropenia; Lenalidomide; Adverse effect; Refractory (planetary science); Gastroenterology; Phases of clinical research; Multiple myeloma; Oncology; Toxicity","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001226236,0.0006206391,0.001317538,0.000308873,0.0003292836,0.0007052324,0.0002919509,0.0005846563,0.002062099],"category_scores_gemma":[0.0004629071,0.0003410425,0.001029859,0.0002149205,0.0003895275,0.0004475357,0.0003128189,0.001914093,0.0005209935],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004604773,"about_ca_system_score_gemma":0.0004899409,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003110355,"about_ca_topic_score_gemma":0.0008082881,"domain_scores_codex":[0.9996958,0.00009312732,0.00002185014,0.0000735569,0.00003418095,0.00008159036],"domain_scores_gemma":[0.9995932,0.00005913205,0.00006490156,0.00003704329,0.00002308159,0.0002226051],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.3914909,0.09469305,0.05952857,0.0008700082,0.002043265,0.000828287,0.0008001454,0.003838151,0.1530733,0.0002541472,0.005709929,0.2868704],"study_design_scores_gemma":[0.09370361,0.783434,0.09881788,0.00005892636,0.0006950096,0.0009871561,0.000127887,0.001354486,0.01440687,0.0001749923,0.006201646,0.00003759157],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9966344,0.001460477,0.0002184223,0.0001477948,0.00003700384,0.0003913011,0.0004699681,0.00003148455,0.0006092527],"genre_scores_gemma":[0.9951189,0.0007331711,0.0005062817,0.0003333677,0.00005625462,0.0004030713,0.001222912,0.0000102765,0.001615779],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002062099,"threshold_uncertainty_score":0.006898463,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01289357455479796,"score_gpt":0.2703263182065431,"score_spread":0.2574327436517451,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}