{"id":"W2905463162","doi":"10.1001/jamaoncol.2018.5877","title":"Assessment of Frequency and Reporting of Changes in Cancer Trial Design After Initiation of Patient Accrual","year":2018,"lang":"en","type":"letter","venue":"JAMA Oncology","topic":"Statistical Methods in Clinical Trials","field":"Mathematics","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Princess Margaret Cancer Centre","funders":"Vetenskapsrådet; National Natural Science Foundation of China","keywords":"Medicine; Accrual; Clinical trial; Research design; Clinical study design; Oncology; Drug trial; Internal medicine; Statistics; Accounting","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":["metaresearch"],"consensus_categories":["metaresearch"],"category_scores_codex":[0.3848148,0.0003855623,0.0009156124,0.006205075,0.001850572,0.004973366,0.002206215,0.006393353,0.004072156],"category_scores_gemma":[0.8336029,0.0008111997,0.001209053,0.009070423,0.002487245,0.005240678,0.003109177,0.006371744,0.002454069],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00768047,"about_ca_system_score_gemma":0.006201298,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003309559,"about_ca_topic_score_gemma":0.003815257,"domain_scores_codex":[0.4331778,0.3916671,0.08805469,0.01031239,0.0727175,0.004070508],"domain_scores_gemma":[0.06986042,0.5988531,0.20248,0.07135125,0.05482512,0.002630246],"domain_codex":null,"domain_gemma":"reporting","domain_candidate":"reporting","domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"observational","study_design_scores_codex":[0.008807206,0.0004403078,0.3392664,0.001991783,0.0006892872,0.0005934235,0.006391054,0.001758822,0.001314642,0.01379746,0.2149298,0.4100199],"study_design_scores_gemma":[0.002645387,0.004721064,0.5014271,0.005350129,0.0007980297,0.004179703,0.004815031,0.02432843,0.009706621,0.04193852,0.3992361,0.0008538762],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"commentary","genre_gemma":"empirical","genre_scores_codex":[0.2512447,0.01013197,0.09687506,0.5142221,0.013048,0.009029931,0.02785975,0.002265975,0.07532248],"genre_scores_gemma":[0.784059,0.002493164,0.05917114,0.1231899,0.006093917,0.01183525,0.00486046,0.0006267385,0.007670254],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.6151852,"threshold_uncertainty_score":0.7586329,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.665240267925091,"score_gpt":0.6166713619402905,"score_spread":0.04856890598480046,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}