{"id":"W2905518644","doi":"10.1042/bcj20180545","title":"Ca2+-dependent calmodulin binding to cardiac ryanodine receptor (RyR2) calmodulin-binding domains","year":2018,"lang":"en","type":"article","venue":"Biochemical Journal","topic":"Cardiac electrophysiology and arrhythmias","field":"Medicine","cited_by":37,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia; Libin Cardiovascular Institute of Alberta; University of Calgary","funders":"Canadian Institutes of Health Research; Lundbeckfonden; H. Lundbeck A/S; Novo Nordisk Fonden; Danmarks Frie Forskningsfond; Heart and Stroke Foundation of Canada","keywords":"Ryanodine receptor; Ryanodine receptor 2; Calmodulin; Biophysics; Affinities; Endoplasmic reticulum; Chemistry; Binding site; Calcium; Crystallography; Biology; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.00058262,0.0003724012,0.0007593483,0.0002778335,0.0004414692,0.00006153905,0.0002240046,0.0003819169,0.0006380919],"category_scores_gemma":[0.000474517,0.0003131645,0.0005210938,0.0004389032,0.0002330505,0.00008509422,0.0001685007,0.001092662,0.001373664],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005402444,"about_ca_system_score_gemma":0.0002499047,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001292535,"about_ca_topic_score_gemma":9.185048e-7,"domain_scores_codex":[0.9971473,0.0001316967,0.0005956354,0.000583542,0.0005899978,0.0009518745],"domain_scores_gemma":[0.9979996,0.0001059645,0.0001706349,0.000421053,0.0003073989,0.000995347],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0007848762,0.00009245385,0.001055093,0.00001918197,0.0002541085,0.0003021777,0.000175677,0.000002596153,0.9523418,0.00003907524,0.04291432,0.002018648],"study_design_scores_gemma":[0.001942658,0.00115084,0.001626435,0.0002907836,0.0002482903,0.002945772,0.0001563577,0.00002688465,0.969397,0.00007855911,0.02158428,0.0005521475],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9930847,0.0004378203,0.0003322927,0.002452356,0.002066603,0.000339619,0.00006284661,0.00008725103,0.001136526],"genre_scores_gemma":[0.9834467,0.0001733734,0.003225835,0.0007874005,0.01063008,0.00001676531,0.00005732953,0.00006566814,0.001596883],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02133005,"threshold_uncertainty_score":0.9999321,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01179457699060873,"score_gpt":0.2746747660588197,"score_spread":0.262880189068211,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}