{"id":"W2905529840","doi":"10.1200/jco.18.01585","title":"<i>EGFR</i> -Mutant Adenocarcinomas That Transform to Small-Cell Lung Cancer and Other Neuroendocrine Carcinomas: Clinical Outcomes","year":2018,"lang":"en","type":"article","venue":"Journal of Clinical Oncology","topic":"Lung Cancer Research Studies","field":"Medicine","cited_by":471,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; Centre hospitalier universitaire de Québec","funders":"National Cancer Institute; Foundation Medicine; Pharmacyclics; Genentech; Incyte; Five Prime Therapeutics; Syndax Pharmaceuticals; Clovis Oncology; Exelixis; Alexion Pharmaceuticals; Amgen; Ariad Pharmaceuticals; Gilead Sciences; Jounce Therapeutics; Celgene; Bristol-Myers Squibb; Eli Lilly and Company; AstraZeneca; Pfizer; Stop Cancer","keywords":"Medicine; T790M; Internal medicine; Oncology; Epidermal growth factor receptor; Lung cancer; Adenocarcinoma; Cancer; Cancer research; Gefitinib","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004419961,0.0002655975,0.0002888851,0.00049721,0.0003696444,0.0005458164,0.0002479384,0.0002929821,0.001112341],"category_scores_gemma":[0.001827603,0.0001222561,0.0002989433,0.000455703,0.0003864574,0.0004316062,0.0004724629,0.000367111,0.0002933933],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003041931,"about_ca_system_score_gemma":0.0002497511,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000924113,"about_ca_topic_score_gemma":0.001452992,"domain_scores_codex":[0.9995726,0.00007243001,0.00006701877,0.00008744915,0.00009705203,0.0001035808],"domain_scores_gemma":[0.9980413,0.0002609454,0.00106996,0.00008522211,0.0001611005,0.000381465],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0001163707,0.00001861984,0.9969609,0.000007820463,0.00001647448,0.0003359321,0.00002059372,0.00004368053,0.0002956504,0.000009113441,0.00006001435,0.002114862],"study_design_scores_gemma":[0.00002021018,0.0003356766,0.9918236,0.00001337803,0.00004094383,0.006729327,0.0001376144,0.00023031,0.000330622,0.00003830864,0.0002950132,0.00000495499],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9991048,0.0002221514,0.00007403552,0.00002010926,0.000003325312,0.00001143008,0.0001314736,0.000003943437,0.0004288081],"genre_scores_gemma":[0.9994569,0.00006512874,0.00004282497,0.00001231853,0.000009419784,0.000006271734,0.000339437,0.00000121809,0.00006650665],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001112341,"threshold_uncertainty_score":0.003721178,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1810748009524502,"score_gpt":0.5113336326705391,"score_spread":0.3302588317180889,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}