{"id":"W2905529840","doi":"10.1200/jco.18.01585","title":"<i>EGFR</i> -Mutant Adenocarcinomas That Transform to Small-Cell Lung Cancer and Other Neuroendocrine Carcinomas: Clinical Outcomes","year":2018,"lang":"en","type":"article","venue":"Journal of Clinical Oncology","topic":"Lung Cancer Research Studies","field":"Medicine","cited_by":471,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; Centre hospitalier universitaire de Québec","funders":"National Cancer Institute; Foundation Medicine; Pharmacyclics; Genentech; Incyte; Five Prime Therapeutics; Syndax Pharmaceuticals; Clovis Oncology; Exelixis; Alexion Pharmaceuticals; Amgen; Ariad Pharmaceuticals; Gilead Sciences; Jounce Therapeutics; Celgene; Bristol-Myers Squibb; Eli Lilly and Company; AstraZeneca; Pfizer; Stop Cancer","keywords":"Medicine; T790M; Internal medicine; Oncology; Epidermal growth factor receptor; Lung cancer; Adenocarcinoma; Cancer; Cancer research; Gefitinib","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.003272,0.0003088866,0.0026425,0.0002110082,0.0001096376,0.00002305778,0.000371719,0.0002263354,0.0002325084],"category_scores_gemma":[0.002720186,0.0001797019,0.0007562136,0.000217133,0.0008194145,0.0001111061,0.0002230507,0.001674496,0.00002476887],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002802634,"about_ca_system_score_gemma":0.002013766,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002521712,"about_ca_topic_score_gemma":0.0009147424,"domain_scores_codex":[0.9947681,0.0005017174,0.002875893,0.0004930042,0.0006821204,0.0006791409],"domain_scores_gemma":[0.9935991,0.003147676,0.0009527082,0.0003777224,0.0006528845,0.001269877],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.004857719,0.0007756505,0.9334382,0.0001164209,0.0007612116,0.001191509,0.0002961761,7.07167e-7,0.000105216,0.00001982421,0.01597982,0.04245757],"study_design_scores_gemma":[0.01164517,0.0165037,0.7178852,0.0001418065,0.0008761288,0.0004548158,0.0002086677,0.0000429232,0.0004584961,0.00005306666,0.2515515,0.0001785561],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9171441,0.002688064,0.00008458042,0.07166685,0.00256812,0.0007512537,0.0000181533,0.00002288521,0.005055993],"genre_scores_gemma":[0.9626956,0.00327013,0.001261252,0.02711273,0.003714273,0.00002394108,4.323712e-7,0.00005630415,0.001865327],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2355717,"threshold_uncertainty_score":0.732803,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1810748009524502,"score_gpt":0.5113336326705391,"score_spread":0.3302588317180889,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}