{"id":"W2905548067","doi":"10.1002/slct.201801863","title":"Expanding the Alkaline Phosphatase Inhibition, Cytotoxic and Proapoptotic Profile of Biscoumarin‐Iminothiazole and Coumarin‐Triazolothiadiazine Conjugates","year":2018,"lang":"en","type":"article","venue":"ChemistrySelect","topic":"Alkaline Phosphatase Research Studies","field":"Medicine","cited_by":8,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval","funders":"Higher Education Commision, Pakistan; Higher Education Commission, Pakistan","keywords":"Coumarin; Alkaline phosphatase; Cytotoxicity; Chemistry; Apoptosis; Cytotoxic T cell; Stereochemistry; Inhibitory postsynaptic potential; Enzyme; Pharmacology; Biochemistry; In vitro; Biology; Endocrinology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004990331,0.0002770272,0.0004802489,0.00006783109,0.0002949958,0.00003947635,0.0000965901,0.0001034455,0.0003242459],"category_scores_gemma":[0.0009270475,0.00019266,0.00005269083,0.0003582078,0.001459335,0.00009815801,0.0002468086,0.0002821992,0.00001588556],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006025399,"about_ca_system_score_gemma":0.0001825768,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00009138428,"about_ca_topic_score_gemma":0.00001054387,"domain_scores_codex":[0.998319,0.0000299049,0.0004100472,0.0004428623,0.0003568314,0.0004413871],"domain_scores_gemma":[0.9985815,0.0002599681,0.0001743708,0.0003920767,0.0003861021,0.0002060103],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0008943462,0.0002650446,0.01777427,0.001634749,0.0004205317,0.00004311746,0.0008298823,2.773218e-7,0.9619299,0.0002244196,0.01315665,0.002826852],"study_design_scores_gemma":[0.002271117,0.0004425204,0.003516131,0.0002698758,0.000165566,0.0001902493,0.0002858589,0.0002223169,0.991224,0.0002045214,0.001015633,0.0001922195],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9885712,0.008110411,0.00003431153,0.001094425,0.00003058422,0.0008779675,0.0001386318,0.00006427521,0.001078248],"genre_scores_gemma":[0.9969209,0.001277339,0.0004140555,0.000181387,0.0002749671,0.0001145828,0.0002067281,0.00003306107,0.0005769127],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02929413,"threshold_uncertainty_score":0.7856445,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02076513451062764,"score_gpt":0.3054327550400602,"score_spread":0.2846676205294325,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}