{"id":"W2905622152","doi":"10.1111/mmi.14189","title":"Antigenic variation in the Lyme spirochete: detailed functional assessment of recombinational switching at <i>vlsE</i> in the JD1 strain of <i>Borrelia burgdorferi</i>","year":2018,"lang":"en","type":"article","venue":"Molecular Microbiology","topic":"Vector-borne infectious diseases","field":"Immunology and Microbiology","cited_by":18,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"Canadian Institutes of Health Research; Génome Québec; McGill University","keywords":"Biology; Borrelia burgdorferi; Lyme disease; Antigenic variation; Genetics; Borrelia; Spirochaetaceae; Recombination; Gene conversion; Strain (injury); Gene; Inverted repeat; Virology; Genome; Antibody","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002088445,0.0002003078,0.0001727029,0.0002250573,0.0001235751,0.000237534,0.0001279816,0.0001948547,0.0003552874],"category_scores_gemma":[0.0001829506,0.00008208072,0.0001497655,0.0001876519,0.0001574657,0.0001252194,0.0001078846,0.0002500759,0.0001270908],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001214,"about_ca_system_score_gemma":0.0000856913,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005849891,"about_ca_topic_score_gemma":0.0006067655,"domain_scores_codex":[0.9998871,0.0000159775,0.000007903192,0.00003630417,0.00003155551,0.0000211504],"domain_scores_gemma":[0.9998881,0.00002589242,0.0000334376,0.000010447,0.00001511831,0.00002698229],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003002731,0.000008126806,0.0009203524,0.00001177764,0.000002531507,0.0000147326,0.00001921423,0.00003094058,0.9983099,0.00001394523,0.000005984707,0.0006326539],"study_design_scores_gemma":[0.000008953494,0.0004526264,0.1536671,0.000008397692,0.00003898021,0.0006585019,0.0001241332,0.002228513,0.8407747,0.00006846892,0.001957976,0.00001162589],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9977738,0.0002516753,0.001354935,0.00001280653,0.000001666302,0.000005707717,0.0003045983,0.00001950886,0.0002752289],"genre_scores_gemma":[0.9966332,0.0001943937,0.001665374,0.00002191681,0.000002093513,0.000007620472,0.001038399,0.00002013574,0.0004168022],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0005849891,"threshold_uncertainty_score":0.001188517,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008840684871936275,"score_gpt":0.2427310598666287,"score_spread":0.2338903749946924,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}