{"id":"W2905623501","doi":"10.1016/j.jval.2018.09.154","title":"PCN72 - BUDGET IMPACT ANALYSIS OF TISAGENLECLEUCEL FOR THE TREATMENT OF ADULT PATIENTS WITH RELAPSED OR REFRACTORY DIFFUSE LARGE B-CELL LYMPHOMA IN ENGLAND","year":2018,"lang":"en","type":"article","venue":"Value in Health","topic":"CAR-T cell therapy research","field":"Medicine","cited_by":4,"is_retracted":false,"has_abstract":false,"ca_institutions":"Novartis (Canada)","funders":"","keywords":"Medicine; Cytokine release syndrome; Diffuse large B-cell lymphoma; Gemcitabine; Rituximab; Hematopoietic stem cell transplantation; Oncology; Salvage therapy; Internal medicine; Lymphoma; Immunotherapy; Transplantation; Chemotherapy; Cancer; Chimeric antigen receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.004594718,0.0006732582,0.001433851,0.001216771,0.0002437236,0.001451915,0.001053761,0.0008612128,0.005051133],"category_scores_gemma":[0.01302861,0.0004666868,0.002555596,0.001793931,0.0005217427,0.0007501385,0.00139148,0.001393688,0.0002774341],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.01576608,"about_ca_system_score_gemma":0.01217065,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.1784016,"about_ca_topic_score_gemma":0.1630031,"domain_scores_codex":[0.994459,0.00341501,0.0002577524,0.0001919928,0.000707784,0.0009685384],"domain_scores_gemma":[0.9948549,0.002152926,0.001111788,0.0001382961,0.0006212816,0.001120661],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"simulation_or_modeling","study_design_gemma":"not_applicable","study_design_scores_codex":[0.09984998,0.002198546,0.09345225,0.005032686,0.008585611,0.001062369,0.0003355558,0.5267168,0.002478655,0.01077125,0.02963517,0.2198812],"study_design_scores_gemma":[0.03578718,0.03752679,0.6501165,0.003201342,0.01261363,0.001174065,0.002284564,0.1700812,0.003132838,0.006394076,0.07733492,0.0003528857],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9159272,0.01525774,0.002272096,0.009326476,0.000278746,0.001667367,0.03364946,0.0001194849,0.02150143],"genre_scores_gemma":[0.9884935,0.002116709,0.000907535,0.0007286927,0.00004346851,0.0003869884,0.005003358,0.00002321367,0.002296497],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1784016,"threshold_uncertainty_score":0.3547264,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03206869418140544,"score_gpt":0.3437703595405243,"score_spread":0.3117016653591188,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}