{"id":"W2905648583","doi":"10.1158/2326-6074.tumimm17-pr03","title":"Abstract PR03: Genetic mechanisms of immune evasion in colorectal cancer","year":2018,"lang":"en","type":"article","venue":"Cancer Immunology Research","topic":"Genetic factors in colorectal cancer","field":"Medicine","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ontario Institute for Cancer Research","funders":"","keywords":"Microsatellite instability; Loss of heterozygosity; Biology; Colorectal cancer; Immune checkpoint; Immune system; Cancer research; Cancer; Exome sequencing; Human leukocyte antigen; Exome; Transcriptome; Immunotherapy; Gene; Genetics; Antigen; Mutation; Allele; Microsatellite; Gene expression","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0009502314,0.0002291329,0.0005873813,0.0006201438,0.0001286426,0.00001189739,0.0004512914,0.0004110252,0.004699275],"category_scores_gemma":[0.000335642,0.0002082123,0.00011191,0.001076787,0.001464947,0.00005449176,0.0003044786,0.001004188,0.0001075493],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000901474,"about_ca_system_score_gemma":0.001536887,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00426844,"about_ca_topic_score_gemma":0.001428607,"domain_scores_codex":[0.9969389,0.0002105444,0.0006371117,0.0005800548,0.0006993882,0.0009339273],"domain_scores_gemma":[0.9979903,0.0002282607,0.0001422463,0.0005219482,0.001002197,0.0001150888],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002100951,0.0001749274,0.02266962,0.0001294815,0.0001507842,0.00003250805,0.0007064568,0.00001143149,0.9530866,0.00008550155,0.000309669,0.02054213],"study_design_scores_gemma":[0.001313564,0.001192741,0.4769452,0.0002738971,0.00001659626,0.00001932724,0.0002086979,0.00005290008,0.5188796,0.0006206,0.0003656515,0.0001112363],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9830181,0.01153956,0.00002540413,0.0007800955,0.001084767,0.001036926,0.00002476298,0.00003409377,0.002456322],"genre_scores_gemma":[0.9952529,0.002798997,0.00048397,0.00006889606,0.0002342293,0.0006783768,0.000006541,0.00005563249,0.0004204237],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4542756,"threshold_uncertainty_score":0.9962106,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0740276616415938,"score_gpt":0.4108042553806031,"score_spread":0.3367765937390093,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}