{"id":"W2905817704","doi":"10.1186/s40425-018-0479-7","title":"High and low mutational burden tumors versus immunologically hot and cold tumors and response to immune checkpoint inhibitors","year":2018,"lang":"en","type":"article","venue":"Journal for ImmunoTherapy of Cancer","topic":"Cancer Immunotherapy and Biomarkers","field":"Medicine","cited_by":571,"is_retracted":false,"has_abstract":true,"ca_institutions":"Lawson Health Research Institute; Western University","funders":"Canadian Institutes of Health Research","keywords":"Immune system; Immunotherapy; Medicine; Melanoma; Phenotype; Immune checkpoint; Immunology; Cancer research; Cancer; Biology; Internal medicine; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004240493,0.00009942919,0.0002693332,0.0004008813,0.0001345975,0.0004491202,0.0001147578,0.0003010911,0.002478888],"category_scores_gemma":[0.001473494,0.0000659459,0.0002306155,0.0002577237,0.0001909928,0.0003659014,0.000183481,0.0004243883,0.0002113525],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001892554,"about_ca_system_score_gemma":0.0001082216,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002981972,"about_ca_topic_score_gemma":0.0005670011,"domain_scores_codex":[0.9997111,0.0000813513,0.00002578901,0.00004773483,0.0000539481,0.00008011283],"domain_scores_gemma":[0.9988291,0.0003680022,0.0004539984,0.00004221554,0.00005756429,0.0002491393],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.008600721,0.0002702772,0.9520963,0.00007633741,0.0001794053,0.0002869299,0.0001020681,0.0003431072,0.009671254,0.0002221316,0.0007601972,0.02739131],"study_design_scores_gemma":[0.00002591675,0.0006232691,0.9967344,0.00001123089,0.00005277097,0.0005406546,0.0001227305,0.0002736599,0.000836559,0.0001656199,0.0006085113,0.000004684843],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9966462,0.001439722,0.000109995,0.0001639222,0.0000166441,0.000008418159,0.0001944391,0.000006125661,0.00141452],"genre_scores_gemma":[0.9990911,0.0001609745,0.00005302874,0.00005653764,0.00002149175,0.000006898435,0.0001561111,0.000002285278,0.0004515794],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002478888,"threshold_uncertainty_score":0.008292735,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01551774962185,"score_gpt":0.3085602037906005,"score_spread":0.2930424541687505,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}