{"id":"W2905948744","doi":"10.1158/1078-0432.ccr-18-1726","title":"SMAD4 Loss in Colorectal Cancer Patients Correlates with Recurrence, Loss of Immune Infiltrate, and Chemoresistance","year":2018,"lang":"en","type":"article","venue":"Clinical Cancer Research","topic":"Cancer Immunotherapy and Biomarkers","field":"Medicine","cited_by":100,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"Office of Extramural Research, National Institutes of Health; National Cancer Institute; Society of Memorial Sloan Kettering; National Institute of Diabetes and Digestive and Kidney Diseases; Stand Up To Cancer; Association for Academic Surgery; Memorial Sloan-Kettering Cancer Center; American Society of Colon and Rectal Surgeons; American College of Surgeons; U.S. Department of Veterans Affairs; Dana-Farber/Harvard Cancer Center; Howard Hughes Medical Institute","keywords":"Cohort; Medicine; Interquartile range; Colorectal cancer; Internal medicine; Oncology; Cancer; Immune system; Chemotherapy; Gastroenterology; Adjuvant therapy; Immunology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003013863,0.0001823541,0.0002583279,0.0003590372,0.0002383269,0.0002951729,0.0002176629,0.0002677165,0.001324098],"category_scores_gemma":[0.0008888592,0.000165501,0.0002522817,0.0003072186,0.0002070535,0.0002133476,0.0001878229,0.0003232663,0.000172592],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001994741,"about_ca_system_score_gemma":0.0001853664,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008402987,"about_ca_topic_score_gemma":0.001235424,"domain_scores_codex":[0.9998571,0.00003238972,0.00001707629,0.00003523447,0.00002611951,0.00003213687],"domain_scores_gemma":[0.9993796,0.0001192114,0.0003092904,0.00005153188,0.0000443318,0.00009595406],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0008630276,0.00003306547,0.9953421,0.000007307145,0.00002908141,0.0001057635,0.00001636664,0.00004871121,0.002272666,0.000007942897,0.00005565728,0.001218298],"study_design_scores_gemma":[0.00002288974,0.000274309,0.9978591,0.000002317825,0.00003538781,0.0007412976,0.00004877584,0.0003080747,0.0005739499,0.00001681825,0.0001142589,0.00000273416],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9997212,0.00007339521,0.00003574992,0.00001141055,0.000001467646,0.000002254856,0.00007724,0.000001773176,0.00007561353],"genre_scores_gemma":[0.9996558,0.00002310806,0.00004381418,0.000006018447,0.000004023847,0.000003107034,0.0001912495,6.356142e-7,0.00007214519],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001324098,"threshold_uncertainty_score":0.004429519,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07200764511862745,"score_gpt":0.4443375698646952,"score_spread":0.3723299247460677,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}