{"id":"W2905955227","doi":"10.1182/blood.v130.suppl_1.lba-1.lba-1","title":"Results of the Randomized, Double-Blind, Placebo-Controlled, Phase 3 Hercules Study of Caplacizumab in Patients with Acquired Thrombotic Thrombocytopenic Purpura","year":2017,"lang":"en","type":"article","venue":"Blood","topic":"Complement system in diseases","field":"Immunology and Microbiology","cited_by":19,"is_retracted":false,"has_abstract":true,"ca_institutions":"St. Michael's Hospital","funders":"","keywords":"Medicine; Thrombotic microangiopathy; Von Willebrand factor; ADAMTS13; Gastroenterology; Internal medicine; Immunosuppression; Thrombotic thrombocytopenic purpura; Platelet; Schistocyte; Clinical endpoint; Immunology; Randomized controlled trial; Disease","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002266633,0.001392132,0.002751059,0.0003478931,0.0004652379,0.00108274,0.0007742583,0.001949492,0.005450743],"category_scores_gemma":[0.002001281,0.0005159663,0.001355865,0.0002814238,0.0008183051,0.000908256,0.0002364363,0.002638248,0.0008676553],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005177741,"about_ca_system_score_gemma":0.0009013939,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004731101,"about_ca_topic_score_gemma":0.0009083205,"domain_scores_codex":[0.9990731,0.000549058,0.00004870699,0.0001379138,0.00006485721,0.0001262696],"domain_scores_gemma":[0.9987822,0.0003996086,0.0002414994,0.0001024226,0.000130876,0.0003433986],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9702094,0.007272345,0.000576101,0.0007506862,0.0009481783,0.00004941135,0.00004679301,0.0002546815,0.002732186,0.0000807101,0.001079126,0.01600042],"study_design_scores_gemma":[0.9304492,0.06639997,0.001807378,0.00002843832,0.0002713685,0.00002393637,0.00001234731,0.0001968795,0.0002344848,0.00005368561,0.0005128032,0.000009547999],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9786815,0.009983611,0.0007603961,0.0008420857,0.0006612298,0.004356163,0.001551412,0.0002239506,0.002939634],"genre_scores_gemma":[0.9878036,0.002458382,0.0009891165,0.001359079,0.0004314379,0.003796165,0.001140288,0.00002609129,0.001995849],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005450743,"threshold_uncertainty_score":0.01823461,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02783260831026847,"score_gpt":0.2913480102201069,"score_spread":0.2635154019098384,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}