{"id":"W2905955227","doi":"10.1182/blood.v130.suppl_1.lba-1.lba-1","title":"Results of the Randomized, Double-Blind, Placebo-Controlled, Phase 3 Hercules Study of Caplacizumab in Patients with Acquired Thrombotic Thrombocytopenic Purpura","year":2017,"lang":"en","type":"article","venue":"Blood","topic":"Complement system in diseases","field":"Immunology and Microbiology","cited_by":19,"is_retracted":false,"has_abstract":true,"ca_institutions":"St. Michael's Hospital","funders":"","keywords":"Medicine; Thrombotic microangiopathy; Von Willebrand factor; ADAMTS13; Gastroenterology; Internal medicine; Immunosuppression; Thrombotic thrombocytopenic purpura; Platelet; Schistocyte; Clinical endpoint; Immunology; Randomized controlled trial; Disease","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007853426,0.0002728577,0.001531806,0.000113188,0.0002725933,0.00002995643,0.000987297,0.0001100532,0.0001209495],"category_scores_gemma":[0.0003934077,0.000157546,0.0002147934,0.0000943687,0.0005009565,0.0001493056,0.0002976682,0.0001219395,0.00001735803],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002617695,"about_ca_system_score_gemma":0.0001084289,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008265651,"about_ca_topic_score_gemma":0.001073517,"domain_scores_codex":[0.9972378,0.000826531,0.001083505,0.0003815824,0.0001607777,0.0003097763],"domain_scores_gemma":[0.9965315,0.000421525,0.001359722,0.001491856,0.0001769239,0.00001841712],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9148674,0.01294438,0.06650182,0.00005264223,0.002235056,0.000003658696,0.001376831,0.00001964611,0.001765484,0.0000729436,0.00009574452,0.00006441342],"study_design_scores_gemma":[0.9352827,0.001047479,0.05630553,0.0001834088,0.001107426,0.000002950282,0.0006885271,0.000001712507,0.005189456,0.00002063347,0.000007117189,0.0001630377],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9903057,0.0003654834,0.000001099285,0.00004702406,0.0002930081,0.007956428,0.0001236058,0.00001540783,0.0008922546],"genre_scores_gemma":[0.9993831,0.000005141291,0.000006900003,0.000006032197,0.00001136629,0.0003525229,0.0000436321,0.00001898877,0.0001723283],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02041534,"threshold_uncertainty_score":0.6424541,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02783260831026847,"score_gpt":0.2913480102201069,"score_spread":0.2635154019098384,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}