{"id":"W2906032577","doi":"10.1016/j.ebiom.2018.12.031","title":"SUMOylation regulates LKB1 localization and its oncogenic activity in liver cancer","year":2018,"lang":"en","type":"article","venue":"EBioMedicine","topic":"Ubiquitin and proteasome pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":79,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Comisión de Investigaciones Científicas; Instituto de Salud Carlos III; Composites Innovation Centre; Regione Emilia-Romagna; Optical Wireless Laboratory, Hong Kong University of Science and Technology; Institut National Du Cancer; European Association for the Study of the Liver; Owl Research Institute; Banco Bilbao Vizcaya Argentaria; Biobanco Vasco; Eusko Jaurlaritza; “la Caixa” Foundation; Abbott Laboratories; Fundación Ramón Areces; Fundación BBVA; National Institutes of Health; U.S. Department of Health and Human Services","keywords":"SUMO protein; Cancer research; Biology; Kinase; Cell biology; Ubiquitin; Proteasome; Signal transducing adaptor protein; Signal transduction; Genetics; Gene","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00006095192,0.0001521672,0.00009346713,0.0001100061,0.0001725574,0.0002308994,0.00008075281,0.0001409609,0.001406625],"category_scores_gemma":[0.00007373359,0.0001001804,0.0001255205,0.0001502856,0.0001456024,0.0001085736,0.0001329915,0.0001680325,0.0004151683],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002675928,"about_ca_system_score_gemma":0.0001234056,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004469964,"about_ca_topic_score_gemma":0.0005319731,"domain_scores_codex":[0.9999555,0.000007256464,0.000003535321,0.000008429511,0.00001195491,0.0000133378],"domain_scores_gemma":[0.9999506,0.000005495439,0.0000195365,0.000004239825,0.000007743412,0.00001231633],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002422083,0.00001205777,0.002180098,0.00005543793,0.000006206222,0.0001347918,0.00002410268,0.00009916139,0.9957041,0.0001309896,0.0000619088,0.001348822],"study_design_scores_gemma":[0.0000231102,0.0001674126,0.03054894,0.00000794483,0.00002798029,0.0008291163,0.00008169918,0.001232463,0.9615581,0.0001390364,0.005378293,0.000005861068],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9963695,0.001714172,0.0007017039,0.0000832158,0.00001030907,0.000006414992,0.0001290022,0.00003255379,0.0009530785],"genre_scores_gemma":[0.9982929,0.0005252121,0.0002620029,0.00001381233,0.00000215386,0.000005132841,0.0001296433,0.000005840973,0.0007633105],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001406625,"threshold_uncertainty_score":0.004705667,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01668872912141411,"score_gpt":0.2777194048619906,"score_spread":0.2610306757405765,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}