{"id":"W2906129219","doi":"10.1182/blood-2018-99-118519","title":"Venetoclax Plus Rituximab, Cyclophosphamide, Doxorubicin, Vincristine and Prednisolone (R-CHOP) Improves Outcomes in BCL2-Positive First-Line Diffuse Large B-Cell Lymphoma (DLBCL): First Safety, Efficacy and Biomarker Analyses from the Phase II CAVALLI Study","year":2018,"lang":"en","type":"article","venue":"Blood","topic":"Lymphoma Diagnosis and Treatment","field":"Medicine","cited_by":32,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre hospitalier universitaire de Québec; Hôpital de l'Enfant-Jésus; Jewish General Hospital","funders":"","keywords":"Medicine; Venetoclax; Rituximab; Internal medicine; CHOP; International Prognostic Index; Oncology; Population; Vincristine; Diffuse large B-cell lymphoma; Lymphoma; Cyclophosphamide; Gastroenterology; Chemotherapy; Leukemia; Chronic lymphocytic leukemia","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008191296,0.000368476,0.0006957213,0.0001676548,0.0001417048,0.0005535603,0.0003956661,0.0003325279,0.00159969],"category_scores_gemma":[0.0005096957,0.0001354714,0.0005245883,0.0002278638,0.0002722657,0.0003277836,0.000192058,0.001355586,0.000242405],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004237365,"about_ca_system_score_gemma":0.0004702099,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009046148,"about_ca_topic_score_gemma":0.00267289,"domain_scores_codex":[0.999817,0.00008707883,0.000010007,0.00003536107,0.00002486259,0.00002571344],"domain_scores_gemma":[0.9995937,0.0001019153,0.000113511,0.00003635199,0.00002262463,0.0001318216],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.4722803,0.02651953,0.03099577,0.001652729,0.002736037,0.000191991,0.0002637651,0.002858199,0.06870519,0.0003057101,0.007010041,0.3864808],"study_design_scores_gemma":[0.2700486,0.5253158,0.1746296,0.0002894584,0.002848256,0.001075997,0.0001519915,0.003009167,0.01362624,0.000335396,0.008616714,0.00005277848],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9925526,0.005519073,0.0001022096,0.0002175587,0.00003806234,0.0001280965,0.0003519199,0.00006440382,0.001026071],"genre_scores_gemma":[0.9958663,0.001902634,0.0003750799,0.0002572347,0.00007320115,0.00007781447,0.0008374018,0.000008133462,0.0006022949],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00159969,"threshold_uncertainty_score":0.005351543,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02116876407871913,"score_gpt":0.3110601321079146,"score_spread":0.2898913680291955,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}