{"id":"W2906130861","doi":"10.1016/j.bbi.2018.12.013","title":"The endocannabinoid 2-AG enhances spontaneous remyelination by targeting microglia","year":2018,"lang":"en","type":"article","venue":"Brain Behavior and Immunity","topic":"Neurogenesis and neuroplasticity mechanisms","field":"Neuroscience","cited_by":41,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"Red Española de Esclerosis Múltiple; Ministerio de Economía y Competitividad","keywords":"Remyelination; Microglia; Myelin; Neuroscience; Multiple sclerosis; Axon; Endogeny; Medicine; Endocannabinoid system; Parabiosis; Inflammation; Immunology; Biology; Central nervous system; Internal medicine; Receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001809032,0.0003849873,0.0004678107,0.000291727,0.0001480111,0.0003139336,0.0002421495,0.0004558171,0.001209954],"category_scores_gemma":[0.0001338708,0.0001223089,0.0002411027,0.000142215,0.0002066822,0.0002904086,0.0001825327,0.0006593374,0.0004013475],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00019943,"about_ca_system_score_gemma":0.0002643744,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003934829,"about_ca_topic_score_gemma":0.001029753,"domain_scores_codex":[0.9998273,0.00003241935,0.00001969013,0.0000256076,0.00003275458,0.00006220958],"domain_scores_gemma":[0.9999313,0.000011617,0.00001585016,0.00001053813,0.000009868439,0.00002072062],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004343752,0.0001286386,0.00004355805,0.00006698837,0.00000606944,0.00004222841,0.00001731911,0.0000609328,0.9966137,0.00007419762,0.00004241452,0.002469675],"study_design_scores_gemma":[0.00006578242,0.001675956,0.001913039,0.00001347294,0.00002185123,0.0001439364,0.00002269238,0.0004646389,0.993793,0.00006935358,0.001811439,0.000004834372],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9935695,0.002470121,0.001403769,0.0001283991,0.00005353437,0.00004335139,0.0001760367,0.00008794028,0.002067346],"genre_scores_gemma":[0.9926879,0.001992596,0.002113097,0.0000800827,0.00003963504,0.00009409645,0.000186866,0.00001403812,0.002791615],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001209954,"threshold_uncertainty_score":0.004047692,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0173471063875217,"score_gpt":0.2638538540030362,"score_spread":0.2465067476155145,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}