{"id":"W2906255446","doi":"10.1186/s40425-018-0457-0","title":"PI3Kα/δ inhibition promotes anti-tumor immunity through direct enhancement of effector CD8+ T-cell activity","year":2018,"lang":"en","type":"article","venue":"Journal for ImmunoTherapy of Cancer","topic":"Immune Cell Function and Interaction","field":"Immunology and Microbiology","cited_by":89,"is_retracted":false,"has_abstract":true,"ca_institutions":"AstraZeneca (Canada)","funders":"AstraZeneca","keywords":"PI3K/AKT/mTOR pathway; Tumor microenvironment; Immune system; CD8; Cancer research; T cell; Effector; Cytotoxic T cell; Immunosuppression; Immunotherapy; Biology; Chemistry; Pharmacology; Immunology; Medicine; Cell biology; In vitro; Signal transduction; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001156585,0.0004128455,0.0002367702,0.0001818186,0.00006699296,0.0002316023,0.000210223,0.0001479091,0.001113801],"category_scores_gemma":[0.00006223794,0.00009335436,0.0001488955,0.0001110036,0.0001496973,0.000168167,0.0001286784,0.0009803515,0.0002907693],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001652377,"about_ca_system_score_gemma":0.0002077692,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002272639,"about_ca_topic_score_gemma":0.0004995072,"domain_scores_codex":[0.9998972,0.00001302575,0.00001124411,0.00002323725,0.00002698969,0.00002832526],"domain_scores_gemma":[0.999963,0.000005678379,0.00001181409,0.000005044832,0.000003553452,0.00001082137],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004470925,0.0001381481,0.0001544632,0.00006810202,0.00000945689,0.00001961274,0.000006933684,0.0001729857,0.9925991,0.00007485002,0.00009006423,0.006219211],"study_design_scores_gemma":[0.00008934114,0.001978256,0.00200046,0.00000567078,0.00002580397,0.0001495508,0.000009028429,0.001096901,0.992698,0.00004321714,0.001901337,0.000002434942],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.991761,0.002149687,0.003445513,0.000117528,0.00004531501,0.00007080552,0.0003863416,0.0001755531,0.001848236],"genre_scores_gemma":[0.994943,0.001034395,0.00215745,0.00004558935,0.00001271388,0.00005494181,0.0002492894,0.00001103959,0.001491637],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001113801,"threshold_uncertainty_score":0.003726065,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01591630376453932,"score_gpt":0.30009173386688,"score_spread":0.2841754301023406,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}