{"id":"W2906273639","doi":"10.1016/j.fsi.2018.12.041","title":"Glutamine starvation inhibits snakehead vesiculovirus replication via inducing autophagy associated with the disturbance of endogenous glutathione pool","year":2018,"lang":"en","type":"article","venue":"Fish & Shellfish Immunology","topic":"Autophagy in Disease and Therapy","field":"Medicine","cited_by":17,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of British Columbia","funders":"Guangdong Science and Technology Department; National Natural Science Foundation of China; Department of Education of Guangdong Province; Pakistan Science Foundation","keywords":"Glutathione; Autophagy; Biology; Glutamine; Reactive oxygen species; Buthionine sulfoximine; Biochemistry; Cell biology; Oxidative stress; Intracellular; Apoptosis; Amino acid; Enzyme","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008739701,0.0001919751,0.0002433802,0.0001162485,0.0001681919,0.0002043377,0.0001428587,0.0002385413,0.0008779571],"category_scores_gemma":[0.00009244661,0.00009263174,0.0002612675,0.00006993036,0.0002915562,0.0002018273,0.000233637,0.00038099,0.0001320145],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002576733,"about_ca_system_score_gemma":0.0003807229,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007776449,"about_ca_topic_score_gemma":0.002015916,"domain_scores_codex":[0.9999394,0.00001297499,0.000006764169,0.00001135734,0.000008342865,0.00002110875],"domain_scores_gemma":[0.9999633,0.00000441145,0.000009626997,0.000005134154,0.000004617498,0.0000128636],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001077787,0.00005836845,0.0005827754,0.00005777069,0.0000114774,0.00004571769,0.00001930344,0.00005902466,0.9956678,0.0001430284,0.0001271729,0.002149798],"study_design_scores_gemma":[0.0001507693,0.001545583,0.01802383,0.00001852637,0.00003972862,0.0002935763,0.0001076134,0.001675847,0.9740399,0.0002759615,0.003813341,0.00001549441],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9969285,0.001351554,0.0006139891,0.00009490864,0.00003349277,0.00001538985,0.0001018142,0.00005143869,0.0008089001],"genre_scores_gemma":[0.9971907,0.0004590023,0.0007333797,0.00004282107,0.000007006666,0.00002077708,0.0001809305,0.000006668537,0.001358795],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008779571,"threshold_uncertainty_score":0.002937019,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02220890071019133,"score_gpt":0.247336806252071,"score_spread":0.2251279055418796,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}