{"id":"W2906318621","doi":"10.1085/jgp.201812221","title":"Epilepsy-associated mutations in the voltage sensor of KCNQ3 affect voltage dependence of channel opening","year":2018,"lang":"en","type":"article","venue":"The Journal of General Physiology","topic":"Ion channel regulation and function","field":"Biochemistry, Genetics and Molecular Biology","cited_by":17,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of Neurological Disorders and Stroke; National Institutes of Health; University of Alberta; Citizens United for Research in Epilepsy","keywords":"Potassium channel; Chemistry; Ion channel; Voltage-gated potassium channel; Epilepsy; Biophysics; Biology; Biochemistry; Neuroscience","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008207341,0.00008887737,0.0001945279,0.00006438822,0.0000715767,0.000003504181,0.0002602855,0.00009583172,0.00002216826],"category_scores_gemma":[0.0001956617,0.0000522927,0.00009931286,0.0001556535,0.000202475,0.000007819663,0.00004712799,0.000123643,0.000001883769],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001003772,"about_ca_system_score_gemma":0.00005024646,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00005066901,"about_ca_topic_score_gemma":0.00004641714,"domain_scores_codex":[0.9989629,0.0003275803,0.0003556911,0.00008584926,0.0001318237,0.0001361865],"domain_scores_gemma":[0.9989556,0.00007500759,0.0004925293,0.0001658557,0.0002899228,0.0000210502],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002815969,0.00005941639,0.0002496851,0.000005717268,0.00004742037,7.203596e-7,0.000507267,0.003585135,0.9942666,0.00005460486,0.0007634489,0.0001784471],"study_design_scores_gemma":[0.001627393,0.002628963,0.1205884,0.00004964758,0.00008339706,0.00009243203,0.001373516,0.004857284,0.8664997,0.001548415,0.000483855,0.0001669789],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9961418,0.0001069488,0.003012409,0.0001368523,0.0003441321,0.0001062321,0.000008506971,0.000001292047,0.0001418365],"genre_scores_gemma":[0.9989406,0.00006033569,0.00005381986,0.0001954761,0.0005430634,0.000001817559,0.00001798023,0.000007727284,0.0001791612],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1277668,"threshold_uncertainty_score":0.2132434,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01848137817845078,"score_gpt":0.274365651464092,"score_spread":0.2558842732856412,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}