{"id":"W2906368293","doi":"10.1007/s11825-018-0216-0","title":"The genetics of atypical hemolytic uremic syndrome","year":2018,"lang":"en","type":"review","venue":"Medizinische Genetik","topic":"Complement system in diseases","field":"Immunology and Microbiology","cited_by":52,"is_retracted":false,"has_abstract":true,"ca_institutions":"Muscular Dystrophy Canada; University of Toronto; Hospital for Sick Children","funders":"","keywords":"Atypical hemolytic uremic syndrome; Pathogenesis; Microangiopathic hemolytic anemia; Alternative complement pathway; Complement system; Thrombotic microangiopathy; Mutation; Medicine; Genetics; Immunology; Biology; Gene; Internal medicine; Thrombotic thrombocytopenic purpura; Antibody; Platelet; Disease","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001571065,0.0004429904,0.0005717466,0.001374825,0.0002245919,0.0005719695,0.0003276561,0.0007323093,0.001756629],"category_scores_gemma":[0.0004286444,0.0001042755,0.0002437155,0.0009924477,0.0003231541,0.0004347059,0.0003388626,0.000734266,0.0007199603],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004035306,"about_ca_system_score_gemma":0.0005877045,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009149004,"about_ca_topic_score_gemma":0.0009654289,"domain_scores_codex":[0.9999084,0.00001607184,0.00001454125,0.00001549719,0.0000318265,0.00001356901],"domain_scores_gemma":[0.9998962,0.00004656369,0.00001884759,0.000003149427,0.00002219328,0.00001311528],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00007192356,0.0000470804,0.002701247,0.006023786,0.0001370494,0.01135376,0.0001964628,0.0003474581,0.006114535,0.008732645,0.04067339,0.9236007],"study_design_scores_gemma":[0.00002103112,0.00004322555,0.005322855,0.002569083,0.0001453807,0.1171105,0.0001333568,0.0001100893,0.001389931,0.004588579,0.8685393,0.00002668667],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.00174931,0.9924752,0.0004454043,0.0008084297,0.0002900286,0.000007014099,0.0000468483,0.00002100369,0.004156761],"genre_scores_gemma":[0.01410698,0.9820549,0.0006214085,0.000701221,0.0004843849,0.000007519359,0.0001287635,0.000005769335,0.001889058],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.001756629,"threshold_uncertainty_score":0.005876541,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0595543360100341,"score_gpt":0.3403691618719132,"score_spread":0.2808148258618791,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}