{"id":"W2906557460","doi":"10.1002/jcph.1361","title":"Pharmacokinetics, Pharmacodynamics, and Safety of E6011, a Novel Humanized Antifractalkine (CX3CL1) Monoclonal Antibody: A Randomized, Double‐Blind, Placebo‐Controlled Single‐Ascending‐Dose Study","year":2018,"lang":"en","type":"article","venue":"The Journal of Clinical Pharmacology","topic":"Chemokine receptors and signaling","field":"Medicine","cited_by":23,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Eisai Canada; Eisai","keywords":"Medicine; Pharmacokinetics; Pharmacodynamics; Rheumatoid arthritis; Placebo; Adverse effect; Pharmacology; Internal medicine; Potency; Gastroenterology; Pathology","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001467175,0.001044751,0.002046599,0.0003871862,0.0002762153,0.000609116,0.0005607856,0.001287934,0.001845753],"category_scores_gemma":[0.001102853,0.0006659371,0.0008822877,0.000283898,0.001180852,0.0009137758,0.0002350724,0.001504935,0.0004890798],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004283579,"about_ca_system_score_gemma":0.0007566084,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004120535,"about_ca_topic_score_gemma":0.0005974834,"domain_scores_codex":[0.9993095,0.0003112989,0.00006090855,0.0001161635,0.00008876199,0.0001134233],"domain_scores_gemma":[0.9992374,0.0001638301,0.0001908274,0.00009034461,0.0000647581,0.0002527929],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.8417998,0.04540331,0.00169404,0.0003961106,0.0004509292,0.0000835816,0.00009580814,0.0007555157,0.07925539,0.0001099727,0.0004461558,0.02950934],"study_design_scores_gemma":[0.2809834,0.6952878,0.008409949,0.00001500642,0.0004728337,0.0001269698,0.000027458,0.001039224,0.01243728,0.00009129757,0.001072566,0.00003621098],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9974133,0.0006322446,0.00053736,0.00006736643,0.0000548225,0.0007424897,0.0001794844,0.00003558744,0.0003373163],"genre_scores_gemma":[0.9954039,0.000699943,0.001003691,0.0002538008,0.0001725539,0.001018943,0.0003451566,0.00001508944,0.001086924],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002046599,"threshold_uncertainty_score":0.007759213,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.081837816035069,"score_gpt":0.4485786332011374,"score_spread":0.3667408171660684,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}