{"id":"W2906557460","doi":"10.1002/jcph.1361","title":"Pharmacokinetics, Pharmacodynamics, and Safety of E6011, a Novel Humanized Antifractalkine (CX3CL1) Monoclonal Antibody: A Randomized, Double‐Blind, Placebo‐Controlled Single‐Ascending‐Dose Study","year":2018,"lang":"en","type":"article","venue":"The Journal of Clinical Pharmacology","topic":"Chemokine receptors and signaling","field":"Medicine","cited_by":23,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Eisai Canada; Eisai","keywords":"Medicine; Pharmacokinetics; Pharmacodynamics; Rheumatoid arthritis; Placebo; Adverse effect; Pharmacology; Internal medicine; Potency; Gastroenterology; Pathology","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.01401273,0.0004937246,0.004195638,0.0003821896,0.0002137467,0.00002877053,0.000510173,0.0002330007,0.001629762],"category_scores_gemma":[0.001104572,0.0003027591,0.0009981144,0.0003503521,0.001614238,0.0001681987,0.0002699857,0.001558172,0.000009985706],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007047284,"about_ca_system_score_gemma":0.0003398964,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002695468,"about_ca_topic_score_gemma":0.000005126371,"domain_scores_codex":[0.9920806,0.001503786,0.004707986,0.0004062389,0.0007637981,0.0005376125],"domain_scores_gemma":[0.9885876,0.005941803,0.003415452,0.0002743237,0.001294868,0.0004859593],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.6949101,0.004426762,0.001678124,0.00006030335,0.00428572,0.00006155681,0.00054019,0.00003334807,0.2915022,0.0000142706,0.001006527,0.001480859],"study_design_scores_gemma":[0.9491591,0.004221728,0.0006442559,0.00014331,0.01033307,0.0005887651,0.0002701393,0.01278063,0.01966251,0.00004165536,0.001862829,0.0002919752],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9875032,0.001134678,0.001788868,0.002239328,0.003506481,0.003257384,0.00001440673,0.0000286514,0.0005270016],"genre_scores_gemma":[0.9893781,0.002851323,0.0007707961,0.001128272,0.005564137,0.00001349985,0.00000795595,0.00006677893,0.0002191376],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2718397,"threshold_uncertainty_score":0.9999425,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.081837816035069,"score_gpt":0.4485786332011374,"score_spread":0.3667408171660684,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}