{"id":"W2906592541","doi":"10.1124/mol.118.114231","title":"S29434, a Quinone Reductase 2 Inhibitor: Main Biochemical and Cellular Characterization","year":2018,"lang":"en","type":"article","venue":"Molecular Pharmacology","topic":"Bioactive Compounds and Antitumor Agents","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":27,"is_retracted":false,"has_abstract":false,"ca_institutions":"St. Francis Xavier University","funders":"Natural Sciences and Engineering Research Council of Canada; Servier; Agence Nationale de la Recherche","keywords":"Reactive oxygen species; NAD+ kinase; Enzyme; Reductase; Quinone; Biochemistry; Cytosol; Chemistry; Cell biology; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0003899246,0.0003188397,0.0003163232,0.0001635675,0.000303065,0.00003205239,0.0002418499,0.0003861705,0.002297905],"category_scores_gemma":[0.00002823638,0.0003321202,0.00008864979,0.0002723697,0.0008994796,0.0001112549,0.0001776228,0.0005385033,0.0002339875],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007044206,"about_ca_system_score_gemma":0.00006847706,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000005779587,"about_ca_topic_score_gemma":8.029361e-7,"domain_scores_codex":[0.9977667,0.0005309359,0.000352594,0.0005991702,0.0001478179,0.0006028081],"domain_scores_gemma":[0.9991338,0.00005854234,0.0001466275,0.0001764227,0.0001280356,0.00035663],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003617062,0.0003483583,0.0005337626,0.00003358506,0.0001732668,0.0003367153,0.0002396889,6.188055e-7,0.9830275,0.0003224509,0.01258467,0.00203772],"study_design_scores_gemma":[0.001887455,0.0002505157,0.0004639779,0.000007668649,0.0001881918,0.0001007164,0.00002867272,0.0006151003,0.8844879,0.0001161694,0.1115374,0.0003162271],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9922,0.0005344845,0.001171351,0.001792872,0.002424628,0.000442822,0.00009692719,0.000111566,0.001225385],"genre_scores_gemma":[0.991312,0.0001370005,0.0002712799,0.006405035,0.001162528,0.00005458224,0.0001789944,0.00004443317,0.0004341343],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.09895279,"threshold_uncertainty_score":0.9999131,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04606515854142725,"score_gpt":0.3784326268405444,"score_spread":0.3323674682991171,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}