{"id":"W2906609434","doi":"10.3390/biom9010006","title":"Epibatidine: A Promising Natural Alkaloid in Health","year":2018,"lang":"en","type":"review","venue":"Biomolecules","topic":"Nicotinic Acetylcholine Receptors Study","field":"Biochemistry, Genetics and Molecular Biology","cited_by":92,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Winnipeg","funders":"Fundação para a Ciência e a Tecnologia","keywords":"Epibatidine; Alkaloid; Nicotinic agonist; Chemistry; Acetylcholine receptor; Nicotinic acetylcholine receptor; Drug discovery; Pharmacology; Computational biology; Stereochemistry; Biology; Receptor; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001747168,0.0005481312,0.0006128983,0.001547271,0.0002904972,0.0006833255,0.0004316799,0.0006892548,0.005571994],"category_scores_gemma":[0.0002359657,0.0001689251,0.0003018363,0.0009522127,0.0002799968,0.0009618826,0.0004781596,0.001132411,0.002115924],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003416849,"about_ca_system_score_gemma":0.0005540295,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000626914,"about_ca_topic_score_gemma":0.001590051,"domain_scores_codex":[0.9999224,0.00001017012,0.00001133807,0.00001964494,0.00002732585,0.000009105372],"domain_scores_gemma":[0.9999188,0.00003105545,0.00001322952,0.000003132221,0.00002170163,0.00001200995],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001158993,0.0001022117,0.0003099385,0.02058442,0.0000796945,0.0005444956,0.0001001299,0.0003543765,0.01009501,0.006673044,0.01958888,0.9414518],"study_design_scores_gemma":[0.0000141703,0.0001146004,0.0007858211,0.00121858,0.00005670685,0.001650992,0.00004890492,0.00006691762,0.00158573,0.001563932,0.9928786,0.00001513207],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0006094226,0.9958847,0.0002519957,0.000263764,0.0002128807,0.000007431476,0.00005151928,0.0000158786,0.002702255],"genre_scores_gemma":[0.003501823,0.9941196,0.0003457367,0.0002180678,0.0001419712,0.000008604252,0.00008334927,0.000002937119,0.001577807],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.005571994,"threshold_uncertainty_score":0.01864016,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02851912224345987,"score_gpt":0.3671493432598724,"score_spread":0.3386302210164125,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}