{"id":"W2906609434","doi":"10.3390/biom9010006","title":"Epibatidine: A Promising Natural Alkaloid in Health","year":2018,"lang":"en","type":"review","venue":"Biomolecules","topic":"Nicotinic Acetylcholine Receptors Study","field":"Biochemistry, Genetics and Molecular Biology","cited_by":92,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Winnipeg","funders":"Fundação para a Ciência e a Tecnologia","keywords":"Epibatidine; Alkaloid; Nicotinic agonist; Chemistry; Acetylcholine receptor; Nicotinic acetylcholine receptor; Drug discovery; Pharmacology; Computational biology; Stereochemistry; Biology; Receptor; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0005632468,0.0005846826,0.001230787,0.000201993,0.00008216838,0.00004381352,0.0005591004,0.000414686,0.00001566549],"category_scores_gemma":[0.0002571016,0.0004947035,0.0004501741,0.0003991608,0.0001952295,0.000003042936,0.0003926483,0.000316312,0.00009226782],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001311648,"about_ca_system_score_gemma":0.0007470148,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00009827651,"about_ca_topic_score_gemma":0.0001825189,"domain_scores_codex":[0.9968575,0.000428037,0.0009439152,0.0009415271,0.0002084943,0.0006205817],"domain_scores_gemma":[0.9985386,0.00002565298,0.000540539,0.0006957793,0.0000631344,0.0001363051],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00002722516,0.0002887764,0.00001909419,0.009688372,0.0003055707,0.000005592829,0.00007605578,1.393523e-7,0.00130561,0.00006049705,0.01734308,0.97088],"study_design_scores_gemma":[0.0003201842,0.0002391179,0.000001920215,0.003986519,0.00004387464,0.00006676594,0.00001132003,0.000002038794,0.0006939428,0.000004309925,0.9941452,0.0004847625],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0002203779,0.9976866,0.00009133259,0.00007266452,0.0005024585,0.00110529,0.00004438318,0.00002950377,0.0002473361],"genre_scores_gemma":[0.0002123209,0.9953026,0.001883733,0.0001224653,0.0007849545,0.0001042528,0.0007112277,0.0001183777,0.0007600491],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9768022,"threshold_uncertainty_score":0.9997504,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02851912224345987,"score_gpt":0.3671493432598724,"score_spread":0.3386302210164125,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}