{"id":"W2906621567","doi":"10.1089/crispr.2018.0045","title":"Double-Stranded Biotinylated Donor Enhances Homology-Directed Repair in Combination with Cas9 Monoavidin in Mammalian Cells","year":2018,"lang":"en","type":"article","venue":"The CRISPR Journal","topic":"CRISPR and Genetic Engineering","field":"Biochemistry, Genetics and Molecular Biology","cited_by":15,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University Health Centre; McGill University","funders":"","keywords":"Biotinylation; Homology (biology); CRISPR; Biology; Homology directed repair; Cell biology; Chemistry; Computational biology; Molecular biology; Genetics; DNA; DNA repair; Gene; Nucleotide excision repair","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004443939,0.0003534359,0.0004755224,0.0002247826,0.0001266476,0.0005293952,0.0004068664,0.0004649351,0.001443071],"category_scores_gemma":[0.0001996478,0.0002497002,0.000291177,0.0001584391,0.0002137389,0.0002680273,0.0004913381,0.0006004723,0.0008254789],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003302273,"about_ca_system_score_gemma":0.0002230881,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005895501,"about_ca_topic_score_gemma":0.0007997993,"domain_scores_codex":[0.9994951,0.0001000105,0.00006412354,0.0001382716,0.000144083,0.00005839612],"domain_scores_gemma":[0.9998255,0.0000361433,0.00005044492,0.00003544751,0.00002076822,0.00003168607],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001611998,0.000006516454,0.00002262837,0.00001515803,0.000001767885,0.00001096621,0.000005854859,0.00002510723,0.9994348,0.000060779,0.000008759353,0.0003915121],"study_design_scores_gemma":[0.000003354902,0.00004265475,0.0001984254,0.000001813224,0.000004213239,0.00007872346,0.000003609315,0.0004484422,0.9981187,0.00001179016,0.001086676,0.00000163782],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9334955,0.001849237,0.05798583,0.0001857161,0.000070364,0.0001457747,0.0005179039,0.0006336844,0.005116084],"genre_scores_gemma":[0.9688153,0.000684194,0.02351203,0.00006410962,0.000009638372,0.00005709019,0.0005535057,0.00009336964,0.006210886],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001443071,"threshold_uncertainty_score":0.004827499,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009366188521981598,"score_gpt":0.2826348330960834,"score_spread":0.2732686445741018,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}