{"id":"W2906621567","doi":"10.1089/crispr.2018.0045","title":"Double-Stranded Biotinylated Donor Enhances Homology-Directed Repair in Combination with Cas9 Monoavidin in Mammalian Cells","year":2018,"lang":"en","type":"article","venue":"The CRISPR Journal","topic":"CRISPR and Genetic Engineering","field":"Biochemistry, Genetics and Molecular Biology","cited_by":15,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University Health Centre; McGill University","funders":"","keywords":"Biotinylation; Homology (biology); CRISPR; Biology; Homology directed repair; Cell biology; Chemistry; Computational biology; Molecular biology; Genetics; DNA; DNA repair; Gene; Nucleotide excision repair","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004842197,0.000152888,0.0001535213,0.0001126599,0.00009774773,0.00002784942,0.0002013328,0.0001263204,0.00003704827],"category_scores_gemma":[0.00001669729,0.0001085361,0.00005321712,0.0002311808,0.0001141254,0.000006983797,0.00003410177,0.0002650024,0.000006064219],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002781971,"about_ca_system_score_gemma":0.00005757549,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00014617,"about_ca_topic_score_gemma":0.001308843,"domain_scores_codex":[0.9989938,0.00009936255,0.0002859375,0.0002122545,0.0001055044,0.0003031228],"domain_scores_gemma":[0.999531,0.00001383707,0.00008738414,0.0002122953,0.00009323723,0.00006221351],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0009105534,0.0001217607,0.004121357,0.00001435277,0.00005153286,0.00004996547,0.0006404747,0.0006424934,0.9905089,0.000012803,0.002018193,0.0009076081],"study_design_scores_gemma":[0.002975133,0.0006377741,0.01583185,0.00004674883,0.00001966714,0.0002373254,0.000241795,0.0006667979,0.9764374,0.0000578554,0.002651046,0.0001965507],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9966835,0.0005593081,0.001628883,0.0004361035,0.0002487798,0.0001860484,0.000003391349,0.00002338536,0.000230607],"genre_scores_gemma":[0.998418,0.0002354808,0.0008122746,0.00007774578,0.0001947898,0.000007992609,0.000008791786,0.00001855768,0.0002263253],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01407145,"threshold_uncertainty_score":0.4425973,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009366188521981598,"score_gpt":0.2826348330960834,"score_spread":0.2732686445741018,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}