{"id":"W2906650498","doi":"10.1016/j.cmet.2018.11.015","title":"Cellular Metabolism Is a Major Determinant of HIV-1 Reservoir Seeding in CD4+ T Cells and Offers an Opportunity to Tackle Infection","year":2018,"lang":"en","type":"article","venue":"Cell Metabolism","topic":"HIV Research and Treatment","field":"Immunology and Microbiology","cited_by":192,"is_retracted":false,"has_abstract":false,"ca_institutions":"Centre Hospitalier de l’Université de Montréal","funders":"Janssen Biotech; ViiV Healthcare; Agence Nationale de Recherches sur le Sida et les Hépatites Virales; Sidaction; Gilead Sciences; Institut Pasteur; amfAR, The Foundation for AIDS Research","keywords":"Glycolysis; Biology; Phenotype; Human immunodeficiency virus (HIV); Oxidative phosphorylation; Cell; In vitro; Cell biology; Cytotoxic T cell; Immunology; Metabolism; Genetics; Biochemistry; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005783256,0.0002590893,0.0005315413,0.0004499478,0.0001814841,0.00002523836,0.0002149237,0.0002363221,0.0008151237],"category_scores_gemma":[0.00009127967,0.0002232018,0.00008717471,0.0003408389,0.0002838868,0.0002134213,0.0002045551,0.0002794051,0.0005555367],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003193651,"about_ca_system_score_gemma":0.0001279048,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001525896,"about_ca_topic_score_gemma":0.0001999753,"domain_scores_codex":[0.9980691,0.000360122,0.0003964113,0.0004863607,0.00008934866,0.0005986699],"domain_scores_gemma":[0.998946,0.00006467955,0.0001234915,0.0004635865,0.0001525644,0.0002496574],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002175835,0.0003397676,0.003026969,0.0000430426,0.0000718024,0.00002081334,0.002817476,0.000001065084,0.9876357,0.00006764462,0.001662475,0.004095668],"study_design_scores_gemma":[0.001859471,0.0002701995,0.03018772,0.00002475485,0.00009363933,0.00000882912,0.0002438978,0.0000126001,0.8884945,0.00007495914,0.07852399,0.000205426],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.99549,0.0017246,0.00007399519,0.0001291719,0.000535312,0.0005112113,0.0002051061,0.00003053666,0.001300125],"genre_scores_gemma":[0.996428,0.0003324536,0.0003590088,0.0001458243,0.00009217448,0.00004851665,0.0000781016,0.0000274979,0.002488423],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.09914117,"threshold_uncertainty_score":0.9101905,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02451948345500259,"score_gpt":0.273405418424495,"score_spread":0.2488859349694924,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}