{"id":"W2906650498","doi":"10.1016/j.cmet.2018.11.015","title":"Cellular Metabolism Is a Major Determinant of HIV-1 Reservoir Seeding in CD4+ T Cells and Offers an Opportunity to Tackle Infection","year":2018,"lang":"en","type":"article","venue":"Cell Metabolism","topic":"HIV Research and Treatment","field":"Immunology and Microbiology","cited_by":192,"is_retracted":false,"has_abstract":false,"ca_institutions":"Centre Hospitalier de l’Université de Montréal","funders":"Janssen Biotech; ViiV Healthcare; Agence Nationale de Recherches sur le Sida et les Hépatites Virales; Sidaction; Gilead Sciences; Institut Pasteur; amfAR, The Foundation for AIDS Research","keywords":"Glycolysis; Biology; Phenotype; Human immunodeficiency virus (HIV); Oxidative phosphorylation; Cell; In vitro; Cell biology; Cytotoxic T cell; Immunology; Metabolism; Genetics; Biochemistry; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001597199,0.0002545281,0.0002842709,0.0003059405,0.0003088409,0.001221891,0.0001871389,0.0003634719,0.003021081],"category_scores_gemma":[0.00023909,0.0001949988,0.0001755284,0.0002429079,0.0002180349,0.0006724909,0.0004371417,0.0004467132,0.0004328953],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003423698,"about_ca_system_score_gemma":0.000250792,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004469099,"about_ca_topic_score_gemma":0.0006381907,"domain_scores_codex":[0.9998647,0.00003593993,0.000008006735,0.00002382127,0.00002464898,0.0000429081],"domain_scores_gemma":[0.9998555,0.00002593654,0.00004561055,0.00001151594,0.0000246655,0.00003664027],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0008205529,0.00008468628,0.0144354,0.0001162719,0.00003146502,0.0003056239,0.00006439454,0.0004378594,0.9695943,0.001128078,0.0002392981,0.01274207],"study_design_scores_gemma":[0.00004590281,0.001363377,0.180158,0.00006305939,0.0001039564,0.001559788,0.0006893086,0.006110894,0.7999687,0.002677223,0.007221002,0.00003889544],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.987392,0.004841689,0.002864247,0.0003460651,0.00005065692,0.00003143194,0.0003546396,0.00005353611,0.004065641],"genre_scores_gemma":[0.997346,0.0007098319,0.0008462471,0.00002517516,0.00002079185,0.00001177444,0.000123532,0.00001217044,0.0009044292],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003021081,"threshold_uncertainty_score":0.01010656,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02451948345500259,"score_gpt":0.273405418424495,"score_spread":0.2488859349694924,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}