{"id":"W2906653622","doi":"10.1126/sciimmunol.aau8714","title":"Tuberculosis and impaired IL-23–dependent IFN-γ immunity in humans homozygous for a common <i>TYK2</i> missense variant","year":2018,"lang":"en","type":"article","venue":"Science Immunology","topic":"Immunodeficiency and Autoimmune Disorders","field":"Immunology and Microbiology","cited_by":209,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; University of Ottawa","funders":"Fondo Nacional de Desarrollo Científico y Tecnológico; National Institute of General Medical Sciences; National Cancer Institute; National Health and Medical Research Council; European Research Council; National Institutes of Health; New South Wales Government; Centre National de la Recherche Scientifique; Conselho Nacional de Desenvolvimento Científico e Tecnológico; Medical Research Council; Department of Health and Social Care; National Center for Advancing Translational Sciences; National Human Genome Research Institute; CHIST-ERA; National Institute of Allergy and Infectious Diseases; National Center for Research Resources; Agence Nationale de la Recherche; Consejo Nacional de Ciencia y Tecnología; Stony Wold-Herbert Fund; Damon Runyon Cancer Research Foundation; Agence Nationale de Sécurité du Médicament et des Produits de Santé; St. Giles Foundation; Office of Health and Medical Research; Canadian Institutes of Health Research; Howard Hughes Medical Institute","keywords":"Missense mutation; Biology; Immunity; Tuberculosis; Tyrosine kinase 2; Immunology; Etiology; Genetics; Immune system; Virology; Medicine; Mutation; Gene; Receptor; Pathology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","sts"],"consensus_categories":["sts"],"category_scores_codex":[0.00194751,0.0003958267,0.0006267125,0.0006012258,0.00172386,0.00008438211,0.001129434,0.0004071777,0.0001411922],"category_scores_gemma":[0.0003935059,0.0003713735,0.0001274941,0.0008806123,0.006259936,0.0004087022,0.0005189268,0.0005954128,0.0002343893],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000149047,"about_ca_system_score_gemma":0.0003309334,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00185567,"about_ca_topic_score_gemma":0.0003837166,"domain_scores_codex":[0.9965864,0.0003366491,0.0007006088,0.0008642275,0.00009761616,0.001414428],"domain_scores_gemma":[0.9982498,0.0003066535,0.0002206231,0.000952558,0.0002473178,0.00002302918],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005328797,0.0005462623,0.0005598808,0.00002099673,0.00009391287,0.00003416892,0.005533951,0.000004298641,0.9705309,0.003516745,0.00008864441,0.01853733],"study_design_scores_gemma":[0.02659159,0.01081359,0.2873817,0.0004962539,0.0003842499,0.007457365,0.03110028,0.0006866088,0.5521086,0.02065408,0.05788596,0.004439674],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.981569,0.01375027,0.0001623227,0.0006154049,0.001712589,0.000737736,0.00005264115,0.0001228808,0.001277184],"genre_scores_gemma":[0.9984243,0.0002816923,0.00009487971,0.0003782563,0.000009727317,0.0001134751,0.00005541402,0.00002774573,0.0006145136],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4184223,"threshold_uncertainty_score":0.9998738,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0106182868099466,"score_gpt":0.2552103755704112,"score_spread":0.2445920887604646,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}