{"id":"W2906779174","doi":"10.1021/acs.molpharmaceut.8b00870","title":"Transferrin Receptor-Mediated Uptake at the Blood–Brain Barrier Is Not Impaired by Alzheimer’s Disease Neuropathology","year":2019,"lang":"en","type":"article","venue":"Molecular Pharmaceutics","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":102,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval","funders":"Fonds de Recherche du Québec - Santé; Canadian Institutes of Health Research; Alzheimer Society","keywords":"Transferrin receptor; Blood–brain barrier; Western blot; Internalization; Hippocampus; Cortex (anatomy); Neuropathology; Alzheimer's disease; Transferrin; Cerebral cortex; Human brain; Biology; Pathology; Temporal cortex; Posterior parietal cortex; Neuroscience; Receptor; Medicine; Internal medicine; Central nervous system; Endocrinology; Disease; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002985704,0.0004279202,0.0007028734,0.0005698479,0.0002628744,0.0006034528,0.0002868513,0.0004968847,0.001394361],"category_scores_gemma":[0.000455554,0.0002587519,0.000397321,0.0002693425,0.000522805,0.0004663775,0.0003064376,0.0005807395,0.0004968413],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004063513,"about_ca_system_score_gemma":0.0002316641,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002123014,"about_ca_topic_score_gemma":0.001474494,"domain_scores_codex":[0.9995839,0.00004266749,0.00005702641,0.0001062917,0.00009761174,0.0001125077],"domain_scores_gemma":[0.9995628,0.00003748274,0.0001295671,0.00006088426,0.00009370215,0.0001156388],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0009168424,0.00007095225,0.001627988,0.00007018846,0.00002655882,0.0002811069,0.00008005406,0.00001465275,0.9953945,0.00004569166,0.00007656082,0.001394889],"study_design_scores_gemma":[0.0001207786,0.002189601,0.2305747,0.00005717175,0.0002071681,0.007752907,0.0004334515,0.0008715469,0.7519667,0.0003366377,0.005442939,0.00004641311],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9976146,0.000774728,0.000521183,0.0000354502,0.00001413766,0.00001516729,0.0002873481,0.00003442696,0.0007028834],"genre_scores_gemma":[0.9970476,0.0004673404,0.0004665257,0.00003889924,0.00000722588,0.00003032349,0.0007223972,0.00002298554,0.001196651],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002123014,"threshold_uncertainty_score":0.0046646,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03410170940684781,"score_gpt":0.3308020059970543,"score_spread":0.2967002965902065,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}