{"id":"W2906792477","doi":"10.1016/j.scr.2018.101372","title":"Fibroblast-derived integration-free iPSC line ISRM-NBS1 from an 18-year-old Nijmegen Breakage Syndrome patient carrying the homozygous NBN c.657_661del5 mutation","year":2018,"lang":"en","type":"article","venue":"Stem Cell Research","topic":"CRISPR and Genetic Engineering","field":"Biochemistry, Genetics and Molecular Biology","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Institute of Genetics; Medizinische Fakultät, Heinrich-Heine-Universität Düsseldorf","keywords":"Biology; Induced pluripotent stem cell; LIN28; SOX2; Homeobox protein NANOG; Embryoid body; Embryonic stem cell; Mutation; Cell culture; Molecular biology; KLF4; Reprogramming; Cell biology; Genetics; Cell; Gene","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005072692,0.0002106867,0.0001656633,0.0001006327,0.0003439704,0.0001370475,0.0005903315,0.0001889362,0.000137468],"category_scores_gemma":[0.00008562529,0.0001693712,0.00008451376,0.0002459368,0.0001895314,0.0000128964,0.0003781378,0.0003204141,0.00007425051],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004718559,"about_ca_system_score_gemma":0.0001022844,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006007119,"about_ca_topic_score_gemma":0.0007827205,"domain_scores_codex":[0.9978648,0.0002592574,0.0003061095,0.0005415994,0.0005108301,0.0005174224],"domain_scores_gemma":[0.9982053,0.000110788,0.00006042155,0.00104679,0.0004030276,0.0001736944],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001186092,0.00007555382,0.0001158815,0.0000334085,0.00004845789,0.00004531994,0.001569068,0.0007214415,0.9856854,0.00001415499,0.00276481,0.008807893],"study_design_scores_gemma":[0.0007302454,0.001827123,0.001351042,0.00007796587,0.00001555419,0.00005483673,0.003026972,0.003469809,0.9867479,0.0001394157,0.002264157,0.000295036],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9918891,0.0005068301,0.005121267,0.000153078,0.0001674727,0.0004966377,0.00009885283,0.00003024064,0.001536576],"genre_scores_gemma":[0.9971368,0.00006229636,0.0007101435,0.00006031599,0.0004392572,0.00006472733,0.0003034322,0.00005486385,0.001168218],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.008512857,"threshold_uncertainty_score":0.6906757,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02548272906114249,"score_gpt":0.3386076777391456,"score_spread":0.3131249486780032,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}