{"id":"W2906792477","doi":"10.1016/j.scr.2018.101372","title":"Fibroblast-derived integration-free iPSC line ISRM-NBS1 from an 18-year-old Nijmegen Breakage Syndrome patient carrying the homozygous NBN c.657_661del5 mutation","year":2018,"lang":"en","type":"article","venue":"Stem Cell Research","topic":"CRISPR and Genetic Engineering","field":"Biochemistry, Genetics and Molecular Biology","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Institute of Genetics; Medizinische Fakultät, Heinrich-Heine-Universität Düsseldorf","keywords":"Biology; Induced pluripotent stem cell; LIN28; SOX2; Homeobox protein NANOG; Embryoid body; Embryonic stem cell; Mutation; Cell culture; Molecular biology; KLF4; Reprogramming; Cell biology; Genetics; Cell; Gene","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001417085,0.000280825,0.0003039849,0.0004264527,0.0004196963,0.0002245608,0.0001744916,0.0003513029,0.005038171],"category_scores_gemma":[0.0001772394,0.0001174407,0.0002379954,0.0003272481,0.0001863474,0.0001140456,0.0002005895,0.00045293,0.002093035],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001645633,"about_ca_system_score_gemma":0.0002883034,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002219985,"about_ca_topic_score_gemma":0.003963462,"domain_scores_codex":[0.9998746,0.000008397818,0.00001957886,0.0000339978,0.00004665599,0.00001679337],"domain_scores_gemma":[0.9999317,0.00001257845,0.000009082777,0.00001485693,0.0000127254,0.00001905464],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000132346,0.0000470687,0.00340296,0.00007747642,0.00001624778,0.004735669,0.000223442,0.0001388253,0.9825148,0.0004091565,0.001153823,0.007148137],"study_design_scores_gemma":[0.00009391219,0.0005387729,0.1292947,0.00007487697,0.0001744823,0.04480188,0.0004356979,0.001978019,0.6993901,0.0004160679,0.1227342,0.00006729599],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9486064,0.001498032,0.01323191,0.0003286753,0.0001808805,0.0005908808,0.01394521,0.0003649825,0.02125283],"genre_scores_gemma":[0.9308228,0.002102457,0.01558894,0.0002345182,0.00003787556,0.0004359989,0.03035986,0.0001292662,0.02028831],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005038171,"threshold_uncertainty_score":0.01685435,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02548272906114249,"score_gpt":0.3386076777391456,"score_spread":0.3131249486780032,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}