{"id":"W2906827916","doi":"10.1200/jco.2014.32.15_suppl.5522","title":"Preclinical and early clinical activity of the oral selective inhibitor of nuclear export (SINE) exportin 1 (XPO1) antagonist KPT-330 (Selinexor) in patients (pts) with platinum-resistant/refractory ovarian cancer (OvCa).","year":2014,"lang":"en","type":"article","venue":"Journal of Clinical Oncology","topic":"Nuclear Structure and Function","field":"Biochemistry, Genetics and Molecular Biology","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ozmosis Research (Canada); Princess Margaret Cancer Centre","funders":"","keywords":"Cisplatin; Medicine; Nuclear export signal; In vivo; Cancer; Cancer research; Apoptosis; Ovarian cancer; Refractory (planetary science); In vitro; Pharmacokinetics; Pharmacology; Oncology; Internal medicine; Chemotherapy; Biology; Cell nucleus; Biochemistry; Nucleus","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004879757,0.0006147458,0.0008953459,0.00029168,0.0001774508,0.0005289503,0.0004619996,0.0005554809,0.002393672],"category_scores_gemma":[0.0005579112,0.0002835012,0.0004196129,0.0002982554,0.0005386578,0.0003995339,0.0002283009,0.001316338,0.0004242063],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004437325,"about_ca_system_score_gemma":0.0006598234,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006372238,"about_ca_topic_score_gemma":0.002085338,"domain_scores_codex":[0.9998457,0.00006761939,0.000008688602,0.00002559742,0.00001840556,0.00003391276],"domain_scores_gemma":[0.9997049,0.00005760191,0.00005724933,0.00002871105,0.00002134432,0.0001302428],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.2654809,0.05052295,0.01962063,0.002015495,0.0009157532,0.001134752,0.0009413277,0.005716721,0.392396,0.0006107269,0.004758261,0.2558865],"study_design_scores_gemma":[0.05136806,0.8445873,0.04290391,0.00007804631,0.0005356614,0.00139745,0.000200197,0.001419037,0.04817733,0.0002000226,0.009096709,0.00003617041],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9952025,0.002047474,0.0003166154,0.0001322818,0.00002328812,0.0004503833,0.0005100611,0.00004702339,0.001270359],"genre_scores_gemma":[0.9958483,0.001336668,0.0003893512,0.000099015,0.00003159963,0.000246589,0.0008652742,0.00001025632,0.001173055],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002393672,"threshold_uncertainty_score":0.008007586,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03223171022178561,"score_gpt":0.3593790091952818,"score_spread":0.3271472989734962,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}