{"id":"W2906827916","doi":"10.1200/jco.2014.32.15_suppl.5522","title":"Preclinical and early clinical activity of the oral selective inhibitor of nuclear export (SINE) exportin 1 (XPO1) antagonist KPT-330 (Selinexor) in patients (pts) with platinum-resistant/refractory ovarian cancer (OvCa).","year":2014,"lang":"en","type":"article","venue":"Journal of Clinical Oncology","topic":"Nuclear Structure and Function","field":"Biochemistry, Genetics and Molecular Biology","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ozmosis Research (Canada); Princess Margaret Cancer Centre","funders":"","keywords":"Cisplatin; Medicine; Nuclear export signal; In vivo; Cancer; Cancer research; Apoptosis; Ovarian cancer; Refractory (planetary science); In vitro; Pharmacokinetics; Pharmacology; Oncology; Internal medicine; Chemotherapy; Biology; Cell nucleus; Biochemistry; Nucleus","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002804592,0.0001938054,0.001173037,0.00005808758,0.00005160683,0.000008884786,0.000251687,0.0007058405,0.00002243941],"category_scores_gemma":[0.002810506,0.0001235308,0.0003112259,0.0001297004,0.0006249995,0.00002568011,0.0001432914,0.0009899688,5.469363e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003843083,"about_ca_system_score_gemma":0.0006930404,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00008641936,"about_ca_topic_score_gemma":0.0003253239,"domain_scores_codex":[0.9955868,0.0009798304,0.00252902,0.0003563252,0.0003282036,0.0002198519],"domain_scores_gemma":[0.9949815,0.0005137642,0.003487143,0.0003050325,0.0005336234,0.0001789822],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0191297,0.001523623,0.906664,0.00002479276,0.0002634124,0.000005387103,0.0000697685,0.00001026346,0.01202616,0.00002363597,0.001195586,0.05906369],"study_design_scores_gemma":[0.00661253,0.02080059,0.9561136,0.00006668804,0.0001413959,0.000008588023,0.00003137981,0.00002388912,0.001713793,0.00005486709,0.01429781,0.0001348358],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9980396,0.00005137148,0.00004247921,0.0003616246,0.0009802022,0.0002052224,0.00001272668,0.000002771265,0.0003040029],"genre_scores_gemma":[0.9976094,0.0001381188,0.0009846553,0.0003359641,0.0008671383,0.000001899379,0.000002431069,0.00002797031,0.00003243002],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.05892886,"threshold_uncertainty_score":0.5444089,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03223171022178561,"score_gpt":0.3593790091952818,"score_spread":0.3271472989734962,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}