{"id":"W2906835339","doi":"10.1002/pros.23754","title":"CUL4B/miR‐33b/C‐MYC axis promotes prostate cancer progression","year":2019,"lang":"en","type":"article","venue":"The Prostate","topic":"Ubiquitin and proteasome pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":32,"is_retracted":false,"has_abstract":true,"ca_institutions":"Public Health Ontario; University of Toronto","funders":"National Natural Science Foundation of China","keywords":"Gene silencing; Cullin; Cancer research; Ubiquitin ligase; Prostate cancer; microRNA; Epigenetics; Biology; Cancer; Chromatin immunoprecipitation; DU145; Molecular biology; Ubiquitin; Gene expression; LNCaP; Promoter; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000381907,0.0002399852,0.0001707289,0.00002710261,0.0001640407,0.00006715718,0.0003243592,0.0001100659,0.0001647738],"category_scores_gemma":[0.00003507758,0.0001524168,0.00009289246,0.000125463,0.0001177919,0.000009257446,0.0002500433,0.0001860239,0.0002410143],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001746672,"about_ca_system_score_gemma":0.0001311588,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004511324,"about_ca_topic_score_gemma":0.00002224486,"domain_scores_codex":[0.998514,0.0001175209,0.0002234695,0.0004536205,0.0002179948,0.0004734239],"domain_scores_gemma":[0.9990736,0.00001199196,0.0001435281,0.000566703,0.0001118544,0.00009233322],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004041791,0.00008604173,0.01698597,0.0001454128,0.00006973196,0.000004283214,0.001179267,0.0000310583,0.9459303,0.0001153993,0.001836402,0.03321198],"study_design_scores_gemma":[0.0007484187,0.0005655129,0.001960445,0.0001082427,0.00001921309,0.00001638841,0.0001118736,0.0001219055,0.8789614,0.0005731665,0.1164913,0.0003221245],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9906214,0.002480699,0.00001488916,0.001473783,0.0002684137,0.001939408,0.0001019728,0.00005678928,0.003042639],"genre_scores_gemma":[0.9867191,0.0005440054,0.0002762559,0.0004005751,0.0002067508,0.0004615422,0.0001176939,0.00005446388,0.01121956],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1146549,"threshold_uncertainty_score":0.6215377,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009616945087548137,"score_gpt":0.2699397477535834,"score_spread":0.2603228026660352,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}