{"id":"W2906861502","doi":"10.1021/acschemneuro.8b00550","title":"<i>N</i>-Guanidyl and <i>C</i>-Tetrazole Leu-Enkephalin Derivatives: Efficient Mu and Delta Opioid Receptor Agonists with Improved Pharmacological Properties","year":2019,"lang":"en","type":"article","venue":"ACS Chemical Neuroscience","topic":"Neuropeptides and Animal Physiology","field":"Neuroscience","cited_by":14,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Université de Sherbrooke","funders":"Institute of Neurosciences, Mental Health and Addiction","keywords":"Chemistry; Lipophilicity; Stereochemistry; Tetrazole; Enkephalin; Peptidomimetic; Receptor; Peptide; Lead compound; Opioid; Biochemistry; In vitro","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009920769,0.0003550457,0.000360833,0.00004886815,0.0002509825,0.0001798246,0.000519234,0.00008072761,0.00002283063],"category_scores_gemma":[0.0003242111,0.0002396354,0.00003798251,0.0004079765,0.001526031,0.0002900321,0.0005676595,0.0004252674,0.00002466381],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002039206,"about_ca_system_score_gemma":0.00005498771,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000008733109,"about_ca_topic_score_gemma":3.143985e-7,"domain_scores_codex":[0.9972298,0.0001004232,0.0002894341,0.001382386,0.0003347123,0.0006633137],"domain_scores_gemma":[0.9990627,0.0002146857,0.000129043,0.0002598596,0.0000467047,0.0002869873],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002355461,0.0001602083,0.0003052839,0.00004064237,0.000001425656,0.00001705249,0.0001064028,0.00002035555,0.9985571,0.0002028416,0.00005173795,0.0003014063],"study_design_scores_gemma":[0.0007815604,0.0007211173,0.0007673439,0.00001994962,0.00001472088,0.0001099535,0.00003879138,0.002212012,0.9931871,0.00002919179,0.001769335,0.0003488879],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9985005,0.00005287926,0.00001291135,0.0003101364,0.0001743961,0.0005839558,0.00002130073,0.0001236404,0.000220283],"genre_scores_gemma":[0.9930129,0.000145897,0.0001623373,0.006407471,0.00004627568,0.00003256223,0.000001137315,0.00003187387,0.0001595449],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006097334,"threshold_uncertainty_score":0.9772047,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0229332505723263,"score_gpt":0.2388114329847691,"score_spread":0.2158781824124427,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}