{"id":"W2906861502","doi":"10.1021/acschemneuro.8b00550","title":"<i>N</i>-Guanidyl and <i>C</i>-Tetrazole Leu-Enkephalin Derivatives: Efficient Mu and Delta Opioid Receptor Agonists with Improved Pharmacological Properties","year":2019,"lang":"en","type":"article","venue":"ACS Chemical Neuroscience","topic":"Neuropeptides and Animal Physiology","field":"Neuroscience","cited_by":14,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Université de Sherbrooke","funders":"Institute of Neurosciences, Mental Health and Addiction","keywords":"Chemistry; Lipophilicity; Stereochemistry; Tetrazole; Enkephalin; Peptidomimetic; Receptor; Peptide; Lead compound; Opioid; Biochemistry; In vitro","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001094763,0.00043258,0.000305296,0.0001064592,0.00005901002,0.000190906,0.0002653704,0.0002613704,0.0004978328],"category_scores_gemma":[0.0001205467,0.0001218188,0.0001931211,0.0001311588,0.0001433105,0.0001822484,0.0001339365,0.0004362109,0.0004920554],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002806117,"about_ca_system_score_gemma":0.0001334588,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002255432,"about_ca_topic_score_gemma":0.0004053598,"domain_scores_codex":[0.9999018,0.00001680788,0.00001167876,0.00001916176,0.00002610649,0.0000244839],"domain_scores_gemma":[0.99992,0.0000070035,0.00003618211,0.000006495302,0.00001106268,0.00001917462],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005318114,0.000005598519,0.00002375778,0.00002141227,0.000001940714,0.00002153122,0.000003278471,0.00005209481,0.9992352,0.00003385273,0.00001606454,0.0005321625],"study_design_scores_gemma":[0.00003625362,0.0004421756,0.0009162353,0.000004514662,0.00001498471,0.0003778572,0.000007269148,0.0004699065,0.9949864,0.00001467761,0.002721342,0.000008390293],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9879616,0.002816071,0.006845769,0.0001114597,0.00004690568,0.00006116318,0.0003417999,0.00008778081,0.001727533],"genre_scores_gemma":[0.9816824,0.001861539,0.01325195,0.00009918908,0.00002077392,0.00007318951,0.0005662481,0.00004192055,0.002402774],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0004978328,"threshold_uncertainty_score":0.002036035,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0229332505723263,"score_gpt":0.2388114329847691,"score_spread":0.2158781824124427,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}