{"id":"W2906875771","doi":"10.1002/em.22253","title":"The development and prevalidation of an <i>in vitro</i> mutagenicity assay based on MutaMouse primary hepatocytes, Part I: Isolation, structural, genetic, and biochemical characterization","year":2018,"lang":"en","type":"article","venue":"Environmental and Molecular Mutagenesis","topic":"Carcinogens and Genotoxicity Assessment","field":"Biochemistry, Genetics and Molecular Biology","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Ottawa; Health Canada","funders":"Natural Sciences and Engineering Research Council of Canada; National Institute of Environmental Health Sciences; Health Canada","keywords":"Biology; Hepatocyte; Molecular biology; Mutagen; In vitro; Fluorescence in situ hybridization; Cell culture; Gene mutation; Biochemistry; Gene; Mutation; Genetics; Chromosome; Carcinogen","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008328331,0.0008860365,0.0005023915,0.0006615723,0.0002572617,0.0005741612,0.0005079522,0.0004130973,0.001541376],"category_scores_gemma":[0.0005601403,0.0004145567,0.0003977806,0.0003892098,0.0003815726,0.0002985121,0.0004671699,0.0007999289,0.001246689],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003219082,"about_ca_system_score_gemma":0.0003373184,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007154499,"about_ca_topic_score_gemma":0.001623199,"domain_scores_codex":[0.9992181,0.0002468578,0.0001344651,0.0001390833,0.0002129048,0.00004865088],"domain_scores_gemma":[0.9992257,0.0001732283,0.000170106,0.0001829617,0.0001796696,0.00006831838],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001405745,0.00001124994,0.0001853181,0.00002317863,0.000002614185,0.0000190703,0.000005942607,0.00002882826,0.9989114,0.00005189939,0.00002346354,0.0007230429],"study_design_scores_gemma":[0.0000021882,0.0001109304,0.001271081,0.000003337893,0.00001104092,0.0001413868,0.000007515426,0.0002431147,0.9969459,0.0000173492,0.001242802,0.000003328611],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"methods","genre_scores_codex":[0.5301488,0.0023505,0.4539078,0.0003316325,0.0001718766,0.001061468,0.003751295,0.001484083,0.006792514],"genre_scores_gemma":[0.6776062,0.004543795,0.2884356,0.0003527264,0.0001030117,0.001569663,0.0131103,0.0005889123,0.01368972],"genre_candidate":"methods","genre_consensus":null,"teacher_disagreement_score":0.001541376,"threshold_uncertainty_score":0.005156398,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004432619360749599,"score_gpt":0.1999422370031023,"score_spread":0.1955096176423528,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}