{"id":"W2906875771","doi":"10.1002/em.22253","title":"The development and prevalidation of an <i>in vitro</i> mutagenicity assay based on MutaMouse primary hepatocytes, Part I: Isolation, structural, genetic, and biochemical characterization","year":2018,"lang":"en","type":"article","venue":"Environmental and Molecular Mutagenesis","topic":"Carcinogens and Genotoxicity Assessment","field":"Biochemistry, Genetics and Molecular Biology","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Ottawa; Health Canada","funders":"Natural Sciences and Engineering Research Council of Canada; National Institute of Environmental Health Sciences; Health Canada","keywords":"Biology; Hepatocyte; Molecular biology; Mutagen; In vitro; Fluorescence in situ hybridization; Cell culture; Gene mutation; Biochemistry; Gene; Mutation; Genetics; Chromosome; Carcinogen","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001768557,0.0001591536,0.0001202538,0.00003113811,0.0001506021,0.00002994791,0.0000619307,0.00009265586,0.000005965157],"category_scores_gemma":[0.000008013921,0.0001363568,0.00002459358,0.00002957539,0.0001991469,0.000007999919,0.00009500864,0.00003882665,5.832269e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002526389,"about_ca_system_score_gemma":0.00002433373,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000005488586,"about_ca_topic_score_gemma":0.000007278364,"domain_scores_codex":[0.9989936,0.0001085581,0.0002326481,0.0003644841,0.0001508056,0.0001499096],"domain_scores_gemma":[0.9996093,0.0000122755,0.00008922453,0.0002032448,0.000009832514,0.00007611498],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001668739,0.00005058874,0.005858097,0.00001584567,0.00001712762,0.00000191329,0.0000639338,0.000009276905,0.9810523,0.000002110447,0.000001883205,0.01276002],"study_design_scores_gemma":[0.0004026704,0.000185429,0.169669,0.000005446001,0.00001772845,0.000006928338,0.0000263236,0.00144445,0.827339,0.000004287384,0.0007609929,0.0001377696],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9975212,0.0003688399,0.001676462,0.00004158593,0.00002525737,0.000300197,0.00005130073,0.000003917838,0.00001129683],"genre_scores_gemma":[0.996619,0.0001749774,0.002328644,0.0002312445,0.00003838003,0.00002768158,0.0005476582,0.00001688103,0.00001556116],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1638109,"threshold_uncertainty_score":0.5560468,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004432619360749599,"score_gpt":0.1999422370031023,"score_spread":0.1955096176423528,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}