{"id":"W2906981998","doi":"10.1182/blood-2018-99-111869","title":"Pomalidomide + Bortezomib + Low-Dose Dexamethasone Vs Bortezomib + Low-Dose Dexamethasone As Second-Line Treatment in Patients with Lenalidomide-Pretreated Multiple Myeloma: A Subgroup Analysis of the Phase 3 Optimismm Trial","year":2018,"lang":"en","type":"article","venue":"Blood","topic":"Multiple Myeloma Research and Treatments","field":"Medicine","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hôpital Fleurimont; Queen Elizabeth II Health Sciences Centre; Dalhousie University","funders":"","keywords":"Pomalidomide; Bortezomib; Dexamethasone; Lenalidomide; Medicine; Multiple myeloma; Internal medicine; Oncology; Subgroup analysis; Thalidomide; Confidence interval","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.003552671,0.001376316,0.003916815,0.0005026904,0.0003352661,0.001525727,0.0007571144,0.001038078,0.002219705],"category_scores_gemma":[0.003000669,0.0003382926,0.008598687,0.0007277476,0.0004620672,0.0007572962,0.0006682478,0.002165942,0.0003218616],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008821847,"about_ca_system_score_gemma":0.0008396528,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006830341,"about_ca_topic_score_gemma":0.001871048,"domain_scores_codex":[0.9981984,0.001089688,0.0001758165,0.0002576896,0.0001341181,0.0001441975],"domain_scores_gemma":[0.9984498,0.0005314725,0.0004470271,0.0001922476,0.00008744468,0.0002919625],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9171903,0.00106612,0.01711145,0.001520691,0.03899353,0.0001381744,0.00007603338,0.00110285,0.001957311,0.0001707884,0.00163339,0.01903932],"study_design_scores_gemma":[0.6549225,0.1096891,0.1141948,0.001056435,0.1022681,0.0005790348,0.0003688588,0.004877229,0.001688096,0.003598226,0.006566633,0.0001909613],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9473541,0.04563204,0.0005748746,0.001260597,0.0006536062,0.001056636,0.001921413,0.00004486418,0.001501896],"genre_scores_gemma":[0.9927794,0.002963421,0.0004628656,0.0008303723,0.0004174057,0.0006311575,0.00145389,0.00001593952,0.0004455011],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003916815,"threshold_uncertainty_score":0.01878858,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01958868565750907,"score_gpt":0.299463498173763,"score_spread":0.279874812516254,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}