{"id":"W2907002983","doi":"10.1371/journal.pone.0209652","title":"Transcriptomic and proteomic host response to Aspergillus fumigatus conidia in an air-liquid interface model of human bronchial epithelium","year":2018,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Antifungal resistance and susceptibility","field":"Medicine","cited_by":30,"is_retracted":false,"has_abstract":true,"ca_institutions":"Prevention of Organ Failure; Simon Fraser University; St. Paul's Hospital; University of British Columbia","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Aspergillus fumigatus; Biology; Transcriptome; Cell biology; Microbiology; A549 cell; Western blot; Shotgun proteomics; Host–pathogen interaction; Proteomics; Cell culture; Gene expression; Gene; Virulence; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001502669,0.0002482157,0.0003390611,0.0002619564,0.0002213586,0.0003122611,0.000117226,0.0003496597,0.0009603181],"category_scores_gemma":[0.0000789886,0.000143496,0.0003170955,0.0002813835,0.0001633027,0.0002028517,0.0002034547,0.0003495739,0.0003465485],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001898884,"about_ca_system_score_gemma":0.0001702283,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001188809,"about_ca_topic_score_gemma":0.001937608,"domain_scores_codex":[0.9998304,0.00002304782,0.00001193406,0.00004917117,0.00005224982,0.00003326868],"domain_scores_gemma":[0.9999489,0.000009788192,0.00001042852,0.000005441878,0.00001512164,0.0000103479],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001072897,0.00001552298,0.0004194451,0.00004213157,0.00000446927,0.00007037592,0.00002408632,0.000043781,0.9988731,0.00001302174,0.00002803438,0.0003587687],"study_design_scores_gemma":[0.00002230816,0.0007932387,0.08496421,0.00002633202,0.00009705685,0.0007620993,0.0007360376,0.004724051,0.9040753,0.00009896178,0.003678418,0.00002197449],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.989613,0.002213872,0.004291407,0.000121952,0.00004409156,0.00006149792,0.002552311,0.00006828228,0.001033542],"genre_scores_gemma":[0.9847711,0.001730232,0.006368105,0.0001740071,0.00002189656,0.0001854484,0.003396104,0.00002422846,0.003328822],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001188809,"threshold_uncertainty_score":0.003212571,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05053150903683833,"score_gpt":0.296388051501222,"score_spread":0.2458565424643837,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}