{"id":"W2907044052","doi":"10.1093/cid/ciy1132","title":"Dolutegravir Monotherapy Versus Dolutegravir/Abacavir/Lamivudine for Virologically Suppressed People Living With Chronic Human Immunodeficiency Virus Infection: The Randomized Noninferiority MONotherapy of TiviCAY Trial","year":2018,"lang":"en","type":"article","venue":"Clinical Infectious Diseases","topic":"HIV/AIDS drug development and treatment","field":"Medicine","cited_by":58,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"University of British Columbia","keywords":"Dolutegravir; Medicine; Abacavir; Lamivudine; Regimen; Adverse effect; Clinical endpoint; Internal medicine; Cumulative incidence; Viral load; Combination therapy; Randomized controlled trial; Resistance mutation; Gastroenterology; Virology; Human immunodeficiency virus (HIV); Transplantation; Virus; Hepatitis B virus; Antiretroviral therapy","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.001444558,0.0005630933,0.001904539,0.0001642135,0.0007131747,0.00009002225,0.000260034,0.0003011436,0.0004628258],"category_scores_gemma":[0.0009813758,0.0003226442,0.001173976,0.0005124144,0.001556054,0.0001673729,0.00007793392,0.0004097653,0.00003796567],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002148113,"about_ca_system_score_gemma":0.0006097397,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000301016,"about_ca_topic_score_gemma":0.0009051225,"domain_scores_codex":[0.9960185,0.0007395007,0.001415518,0.0007802609,0.0004567087,0.000589553],"domain_scores_gemma":[0.9927812,0.004998611,0.0007002511,0.0008212948,0.0004538402,0.0002448102],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.7394938,0.01159324,0.2275088,0.0001617272,0.004728612,0.00001289287,0.000902927,0.00002896273,0.001311002,0.001432613,0.0006481871,0.01217722],"study_design_scores_gemma":[0.7535055,0.01851775,0.220557,0.0002311339,0.00226179,0.000008580342,0.00004059438,0.0004213121,0.0004443293,0.0007364303,0.002688554,0.0005870083],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9871745,0.0008247723,0.00427665,0.0005802786,0.000980845,0.004909296,0.00005689435,0.0002834093,0.0009133815],"genre_scores_gemma":[0.9944697,0.001717101,0.0001530856,0.0002061462,0.00130398,0.001358553,0.00008261717,0.00007389599,0.0006349465],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01401173,"threshold_uncertainty_score":0.9999226,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03736842829765436,"score_gpt":0.3700522766694135,"score_spread":0.3326838483717592,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}