{"id":"W2907044052","doi":"10.1093/cid/ciy1132","title":"Dolutegravir Monotherapy Versus Dolutegravir/Abacavir/Lamivudine for Virologically Suppressed People Living With Chronic Human Immunodeficiency Virus Infection: The Randomized Noninferiority MONotherapy of TiviCAY Trial","year":2018,"lang":"en","type":"article","venue":"Clinical Infectious Diseases","topic":"HIV/AIDS drug development and treatment","field":"Medicine","cited_by":58,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"University of British Columbia","keywords":"Dolutegravir; Medicine; Abacavir; Lamivudine; Regimen; Adverse effect; Clinical endpoint; Internal medicine; Cumulative incidence; Viral load; Combination therapy; Randomized controlled trial; Resistance mutation; Gastroenterology; Virology; Human immunodeficiency virus (HIV); Transplantation; Virus; Hepatitis B virus; Antiretroviral therapy","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00216971,0.001147042,0.002168808,0.0003259273,0.0003196095,0.0009548686,0.0007577145,0.001474004,0.00431777],"category_scores_gemma":[0.001778349,0.0005480996,0.001803003,0.0002560262,0.0009379757,0.0007398856,0.0005373461,0.002309048,0.0005222734],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008154247,"about_ca_system_score_gemma":0.001209109,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001048231,"about_ca_topic_score_gemma":0.002215264,"domain_scores_codex":[0.9990475,0.00062985,0.00005152758,0.0001049328,0.00005217187,0.000113978],"domain_scores_gemma":[0.9990747,0.0003003282,0.000215326,0.00006064867,0.0000641335,0.0002848635],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.987616,0.002058236,0.0004019056,0.0003331608,0.0004877739,0.0000164378,0.00003340046,0.0002060098,0.001183753,0.00005111687,0.0002127884,0.007399325],"study_design_scores_gemma":[0.9468022,0.05084786,0.00106903,0.00003285468,0.0003385221,0.00002217035,0.00001623711,0.0002437427,0.0002258361,0.00007550558,0.0003199079,0.000006048364],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9916824,0.003751702,0.0003070262,0.0005933419,0.0002802579,0.001756679,0.0004802755,0.00004310899,0.001105158],"genre_scores_gemma":[0.9925795,0.001729141,0.0007837446,0.0006307109,0.000337842,0.001802161,0.0005378011,0.00001282996,0.001586286],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00431777,"threshold_uncertainty_score":0.01444435,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03736842829765436,"score_gpt":0.3700522766694135,"score_spread":0.3326838483717592,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}