{"id":"W2907052423","doi":"10.1182/blood-2018-99-111528","title":"Immunotherapy with T-Cells Engineered with a Chimeric Antigen Receptor Bearing a Human CD19-Binding Single Chain Variable Fragment for Relapsed or Refractory Acute Lymphoblastic Leukemia and B-Cell Non-Hodgkin Lymphoma","year":2018,"lang":"en","type":"article","venue":"Blood","topic":"CAR-T cell therapy research","field":"Medicine","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"","keywords":"Fludarabine; Medicine; Cyclophosphamide; Bone marrow; Immunology; CD8; Leukemia; Antigen; Chimeric antigen receptor; Immunotherapy; Lymphoma; Cancer research; Internal medicine; Immune system; Chemotherapy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003174564,0.0003506911,0.0006111577,0.0002321937,0.0001921066,0.0003964654,0.0003727144,0.0004015204,0.001534144],"category_scores_gemma":[0.0001557171,0.0001466294,0.0002737937,0.000161459,0.0003155187,0.0002163884,0.0002317129,0.00098535,0.0003813719],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004634022,"about_ca_system_score_gemma":0.0004547178,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000585943,"about_ca_topic_score_gemma":0.0009593689,"domain_scores_codex":[0.9998407,0.0000450553,0.000009846431,0.00003165623,0.00002178753,0.00005087727],"domain_scores_gemma":[0.9998794,0.00001844296,0.00002219322,0.00001138889,0.000007517381,0.00006112039],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0434444,0.0265777,0.0180912,0.0006167808,0.0002885645,0.001110485,0.0002679106,0.003964769,0.8006519,0.0005581239,0.003219166,0.101209],"study_design_scores_gemma":[0.05409783,0.5725151,0.07001733,0.0000734096,0.0007789783,0.003992568,0.0001941172,0.008314428,0.2713428,0.0003323981,0.01828636,0.00005461517],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9982243,0.0004175483,0.0002132368,0.00005834312,0.00001761137,0.0002274997,0.00009825588,0.0000349848,0.0007081848],"genre_scores_gemma":[0.9978928,0.0002853436,0.0005569826,0.00009294083,0.00002491277,0.0002039889,0.0002767035,0.000006490015,0.0006599521],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001534144,"threshold_uncertainty_score":0.005132198,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01241885722572465,"score_gpt":0.2474329659917588,"score_spread":0.2350141087660342,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}