{"id":"W2907079093","doi":"10.1182/blood-2018-99-110429","title":"Final Analysis of the Front-Line Phase III Randomized ACT-1 Trial in Younger Patients with Systemic Peripheral T-Cell Lymphoma Treated with CHOP Chemotherapy with or without Alemtuzumab and Consolidated By Autologous Hematopoietic Stem Cell Transplant","year":2018,"lang":"en","type":"article","venue":"Blood","topic":"CAR-T cell therapy research","field":"Medicine","cited_by":27,"is_retracted":false,"has_abstract":true,"ca_institutions":"BC Cancer Agency; Spinal Cord Injury BC; University Health Network","funders":"","keywords":"CHOP; Medicine; Alemtuzumab; Internal medicine; Clinical endpoint; Interim analysis; Peripheral T-cell lymphoma; Lymphoma; Randomized controlled trial; Surgery; Oncology; Transplantation; Immunology; Immune system; T cell","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.009071263,0.001379532,0.002087895,0.0003470861,0.0003600058,0.001296422,0.0007929576,0.0009846006,0.005662136],"category_scores_gemma":[0.005773047,0.0004076471,0.003040307,0.0003943398,0.0006616905,0.000861636,0.0004760437,0.00203747,0.0008873592],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0009387025,"about_ca_system_score_gemma":0.001431952,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005082812,"about_ca_topic_score_gemma":0.001253037,"domain_scores_codex":[0.9958289,0.003118904,0.000190799,0.0003651654,0.0002647552,0.0002315093],"domain_scores_gemma":[0.9967924,0.001175132,0.0006898881,0.0003899444,0.0003712235,0.0005813785],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9709466,0.002218551,0.003741423,0.0004131488,0.003896209,0.00007315157,0.00006464074,0.001276808,0.002642864,0.0003187755,0.003338291,0.01106963],"study_design_scores_gemma":[0.8398978,0.1193108,0.02162463,0.0001022692,0.006811952,0.000179579,0.00006469776,0.002852349,0.001714839,0.0007812243,0.006606237,0.00005378769],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9723285,0.004052367,0.002923712,0.00122091,0.000500964,0.00747609,0.007158872,0.0001199429,0.004218616],"genre_scores_gemma":[0.9737587,0.0008133563,0.004014996,0.001156276,0.0003830448,0.005345174,0.01115302,0.00006252509,0.003312939],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.009071263,"threshold_uncertainty_score":0.04797399,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01178255939796034,"score_gpt":0.2600723246321082,"score_spread":0.2482897652341479,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}