{"id":"W2907079093","doi":"10.1182/blood-2018-99-110429","title":"Final Analysis of the Front-Line Phase III Randomized ACT-1 Trial in Younger Patients with Systemic Peripheral T-Cell Lymphoma Treated with CHOP Chemotherapy with or without Alemtuzumab and Consolidated By Autologous Hematopoietic Stem Cell Transplant","year":2018,"lang":"en","type":"article","venue":"Blood","topic":"CAR-T cell therapy research","field":"Medicine","cited_by":27,"is_retracted":false,"has_abstract":true,"ca_institutions":"BC Cancer Agency; Spinal Cord Injury BC; University Health Network","funders":"","keywords":"CHOP; Medicine; Alemtuzumab; Internal medicine; Clinical endpoint; Interim analysis; Peripheral T-cell lymphoma; Lymphoma; Randomized controlled trial; Surgery; Oncology; Transplantation; Immunology; Immune system; T cell","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004467919,0.0004899371,0.002297957,0.0003093322,0.0001001532,0.000041147,0.0002205896,0.0001862714,0.0005184474],"category_scores_gemma":[0.000006699554,0.0002325875,0.0001814838,0.0009682578,0.0007730526,0.00008567818,0.00001852674,0.0002211559,0.000001405993],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001260421,"about_ca_system_score_gemma":0.0004646445,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004761184,"about_ca_topic_score_gemma":0.0003143465,"domain_scores_codex":[0.9968511,0.0004632414,0.0007677887,0.0006251952,0.0007715803,0.0005210422],"domain_scores_gemma":[0.9982238,0.0001874609,0.0004431771,0.0006558515,0.000296702,0.0001930384],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9338173,0.005729269,0.03230419,0.0002056663,0.003518212,0.00007683109,0.004066386,0.000005312566,0.01983738,3.105819e-7,0.00001404051,0.0004250931],"study_design_scores_gemma":[0.9236097,0.00883324,0.0009551554,0.0004140996,0.006286851,0.0001785478,0.0003523251,0.001634478,0.05740276,2.077526e-7,0.00001475826,0.0003178637],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9942707,0.000309487,0.0001070308,0.00003700061,0.00002338772,0.004775634,0.0001312486,0.00005164424,0.0002939006],"genre_scores_gemma":[0.996654,0.00009876806,0.00009075546,0.00007144484,0.00003934748,0.0002271388,0.0001281238,0.00007837837,0.002612065],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03756538,"threshold_uncertainty_score":0.9484642,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01178255939796034,"score_gpt":0.2600723246321082,"score_spread":0.2482897652341479,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}