{"id":"W2907086215","doi":"10.3390/ph12010009","title":"Juvenile Arthritis Patients Suffering from Chronic Inflammation Have Increased Activity of Both IDO and GTP-CH1 Pathways But Decreased BH4 Efficacy: Implications for Well-Being, Including Fatigue, Cognitive Impairment, Anxiety, and Depression","year":2019,"lang":"en","type":"article","venue":"Pharmaceuticals","topic":"Tryptophan and brain disorders","field":"Neuroscience","cited_by":37,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Universiteit Utrecht; Deutsche Forschungsgemeinschaft; Arthritis Society; Dutch Arthritis Society","keywords":"Neopterin; Kynurenine; GTP cyclohydrolase I; Medicine; Tetrahydrobiopterin; Internal medicine; Inflammation; Kynurenine pathway; Arthritis; Endocrinology; Proinflammatory cytokine; Immunology; Tryptophan; Chemistry; Nitric oxide; Biochemistry; Nitric oxide synthase","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001117859,0.0003550146,0.0003554708,0.000469577,0.0004100144,0.0003921188,0.00007807506,0.0002311782,0.001034298],"category_scores_gemma":[0.0002182213,0.0001340605,0.0001799187,0.0005031229,0.0002487765,0.0001828299,0.0001752959,0.0002394148,0.0001094499],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002513921,"about_ca_system_score_gemma":0.0001933077,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002207397,"about_ca_topic_score_gemma":0.005026513,"domain_scores_codex":[0.9998534,0.00002040738,0.00002057909,0.00003390183,0.00003831131,0.00003345583],"domain_scores_gemma":[0.999736,0.00002371998,0.0001582135,0.000007192382,0.00002728448,0.00004751456],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001575621,0.0002735915,0.8214569,0.0003883506,0.0001269926,0.001876573,0.0005938691,0.0000690011,0.1409507,0.00006795181,0.0002265423,0.03239389],"study_design_scores_gemma":[0.00001979996,0.0004381522,0.9946561,0.00001471826,0.00005468664,0.001673676,0.0002296841,0.00005519445,0.002347156,0.00002684609,0.0004777486,0.000006385287],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9946563,0.004524246,0.0001779232,0.00005516053,0.000007675269,0.000009620125,0.0001010318,0.000009104687,0.0004589129],"genre_scores_gemma":[0.9983035,0.001083528,0.0002089352,0.00003289902,0.00001405346,0.000006282337,0.00008984272,0.00000121581,0.000259635],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002207397,"threshold_uncertainty_score":0.004389107,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04636521634735592,"score_gpt":0.3281512406853448,"score_spread":0.2817860243379889,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}