{"id":"W2907086215","doi":"10.3390/ph12010009","title":"Juvenile Arthritis Patients Suffering from Chronic Inflammation Have Increased Activity of Both IDO and GTP-CH1 Pathways But Decreased BH4 Efficacy: Implications for Well-Being, Including Fatigue, Cognitive Impairment, Anxiety, and Depression","year":2019,"lang":"en","type":"article","venue":"Pharmaceuticals","topic":"Tryptophan and brain disorders","field":"Neuroscience","cited_by":37,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Universiteit Utrecht; Deutsche Forschungsgemeinschaft; Arthritis Society; Dutch Arthritis Society","keywords":"Neopterin; Kynurenine; GTP cyclohydrolase I; Medicine; Tetrahydrobiopterin; Internal medicine; Inflammation; Kynurenine pathway; Arthritis; Endocrinology; Proinflammatory cytokine; Immunology; Tryptophan; Chemistry; Nitric oxide; Biochemistry; Nitric oxide synthase","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00020712,0.0002419255,0.0003358761,0.0001092771,0.0002483613,0.00007232869,0.0001362776,0.0001008747,0.00007264175],"category_scores_gemma":[0.0007052946,0.0002432566,0.0000758141,0.0001355091,0.0001593898,0.0003867175,0.000212772,0.000165845,0.000006062062],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006368489,"about_ca_system_score_gemma":0.00006649226,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00009327708,"about_ca_topic_score_gemma":0.00002194804,"domain_scores_codex":[0.9982705,0.0001865039,0.0003539033,0.0006085536,0.0002117761,0.0003687498],"domain_scores_gemma":[0.9977509,0.001480953,0.000253596,0.0001995678,0.00007743965,0.0002375011],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002751784,0.0002618783,0.1273059,0.000116801,0.00001987224,4.557224e-7,0.000399712,0.000006958436,0.8149666,0.0001171146,0.00001633926,0.0565132],"study_design_scores_gemma":[0.00644824,0.0001192037,0.2948009,0.0002197261,0.00003898338,0.000001760749,0.00004956617,0.005074149,0.6921685,0.0007467075,0.0001039505,0.0002282342],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9956332,0.0002270463,0.001279994,0.00008540683,0.00007498114,0.001884826,0.0003707066,0.0000773864,0.0003664274],"genre_scores_gemma":[0.9988174,0.0005871981,0.0001235773,0.0001633638,0.00005479662,0.0001465075,0.00006893161,0.00003297291,0.000005249071],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1674951,"threshold_uncertainty_score":0.9919718,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04636521634735592,"score_gpt":0.3281512406853448,"score_spread":0.2817860243379889,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}