{"id":"W2907177946","doi":"10.1038/s41467-018-07841-3","title":"Ulcerative colitis mucosal transcriptomes reveal mitochondriopathy and personalized mechanisms underlying disease severity and treatment response","year":2018,"lang":"en","type":"article","venue":"Nature Communications","topic":"Inflammatory Bowel Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":388,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children; Children's Hospital of Eastern Ontario","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; National Center for Complementary and Integrative Health; Israeli Centers for Research Excellence; Israel Science Foundation; Crohn's and Colitis Foundation; Shire; Massachusetts Institute of Technology","keywords":"Ulcerative colitis; Transcriptome; Inflammatory bowel disease; Disease; Medicine; Gene; Immunology; Cohort; Colitis; Pathogenesis; Gene signature; Bioinformatics; Gene expression; Biology; Internal medicine; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002892645,0.0001350153,0.0003413587,0.0003283043,0.0002142596,0.0005454874,0.000104648,0.0002403785,0.00152995],"category_scores_gemma":[0.0006122091,0.0001083564,0.0002306584,0.0004456267,0.0002206785,0.0001905464,0.0003513443,0.0002998921,0.0002657464],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001885192,"about_ca_system_score_gemma":0.0001241724,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005983211,"about_ca_topic_score_gemma":0.001002482,"domain_scores_codex":[0.9998293,0.00004066833,0.00001141332,0.00005163123,0.00003336365,0.00003354692],"domain_scores_gemma":[0.9996963,0.00005154585,0.0001484307,0.00003195495,0.00003324241,0.00003854668],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.002150517,0.0000547663,0.7474852,0.0001690554,0.0001933009,0.0002425374,0.0005624283,0.0005046383,0.2250868,0.0001365136,0.0004970634,0.02291729],"study_design_scores_gemma":[0.00001043376,0.0002439094,0.9927978,0.00001632443,0.00004350978,0.0003245339,0.0003611743,0.0004577971,0.004852173,0.0001603294,0.0007259941,0.000006108762],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9979123,0.0005636648,0.0003860275,0.00006849968,0.000003815274,0.000006837054,0.0007735921,0.000009884872,0.0002752889],"genre_scores_gemma":[0.9982758,0.000205569,0.0004477568,0.00005372212,0.000005073081,0.00001185942,0.0006834413,0.00000722985,0.0003095572],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00152995,"threshold_uncertainty_score":0.005118251,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02014129012239532,"score_gpt":0.3029978183136801,"score_spread":0.2828565281912848,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}