{"id":"W2907227169","doi":"10.1182/blood-2018-99-116915","title":"Intralesional Administration of the CD47 Antagonist TTI-621 (SIRPαFc) Induces Responses in Both Injected and Non-Injected Lesions in Patients with Relapsed/Refractory Mycosis Fungoides and Sézary Syndrome: Interim Results of a Multicenter Phase I Trial","year":2018,"lang":"en","type":"article","venue":"Blood","topic":"Phagocytosis and Immune Regulation","field":"Immunology and Microbiology","cited_by":13,"is_retracted":false,"has_abstract":true,"ca_institutions":"Trillium Therapeutics (Canada)","funders":"","keywords":"Medicine; CD47; Pharmacology; Tolerability; Neutropenia; Immune system; Immunology; Internal medicine; Chemotherapy; Adverse effect","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001123269,0.0007922095,0.001300459,0.0002391486,0.0002359427,0.0005875831,0.0003668416,0.0005365594,0.00114584],"category_scores_gemma":[0.0004900285,0.0002689314,0.0008168704,0.0002379931,0.000421497,0.0004608005,0.0002216136,0.001168752,0.0003114384],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004181775,"about_ca_system_score_gemma":0.0004961525,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004173134,"about_ca_topic_score_gemma":0.0009290259,"domain_scores_codex":[0.9997086,0.0001327571,0.00002248288,0.00005423494,0.00002433892,0.00005755402],"domain_scores_gemma":[0.9995308,0.00007373394,0.0001362309,0.0000398215,0.00002673343,0.0001927406],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.61256,0.04019703,0.03812973,0.0007384747,0.001835583,0.0004934196,0.0004082969,0.002246088,0.1603008,0.0001594533,0.001776383,0.1411549],"study_design_scores_gemma":[0.1985805,0.7181302,0.06516884,0.00004858879,0.001036459,0.0006462986,0.0001223903,0.001827283,0.01270101,0.0001070894,0.00159419,0.00003707131],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9982426,0.0008392003,0.0001435729,0.00005596552,0.00001413494,0.00023139,0.0001391201,0.00002400621,0.0003099232],"genre_scores_gemma":[0.9980404,0.0004616489,0.0003190538,0.0001379429,0.00004851778,0.0002732001,0.0003653486,0.000006703474,0.0003473491],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001300459,"threshold_uncertainty_score":0.005940437,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01464885721451163,"score_gpt":0.2620105905146928,"score_spread":0.2473617333001812,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}