{"id":"W2907316332","doi":"10.1182/blood-2018-99-110483","title":"Fostamatinib, a Spleen Tyrosine Kinase Inhibitor, for the Treatment of Warm Antibody Autoimmune Hemolytic Anemia: Initial Results of the Multicenter, Open-Label Extension Period of the Soar Phase 2 Study","year":2018,"lang":"en","type":"article","venue":"Blood","topic":"Blood groups and transfusion","field":"Medicine","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University","funders":"","keywords":"Autoimmune hemolytic anemia; Syk; Medicine; Anemia; Antibody; Internal medicine; Immunology; Gastroenterology; Pharmacology; Tyrosine kinase; Receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002395685,0.001021726,0.001554157,0.0002568401,0.0002841114,0.0008544116,0.0004748488,0.0007624414,0.001531916],"category_scores_gemma":[0.001442202,0.0002202753,0.001372185,0.0002756197,0.0004494433,0.0007532182,0.0002366677,0.001787843,0.0003966226],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007164686,"about_ca_system_score_gemma":0.0008592529,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005363032,"about_ca_topic_score_gemma":0.001621105,"domain_scores_codex":[0.9994054,0.0002807808,0.00004577469,0.00008273958,0.00008414262,0.0001012437],"domain_scores_gemma":[0.9992158,0.0001523952,0.0001815755,0.00005985465,0.0001032362,0.0002870862],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.5010046,0.03713061,0.01793792,0.002684939,0.006073549,0.001299843,0.0008544822,0.004675316,0.08744027,0.0005760612,0.01410227,0.3262201],"study_design_scores_gemma":[0.4069058,0.4990256,0.05851442,0.0001864531,0.002879415,0.002335251,0.0002313989,0.00283784,0.01257815,0.0005081907,0.01389008,0.0001073761],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9879629,0.00694817,0.000725161,0.0008314317,0.00009963573,0.0008489378,0.00124596,0.00005535893,0.001282516],"genre_scores_gemma":[0.9904343,0.003313833,0.001451177,0.0008705665,0.0001327812,0.0006709258,0.002047202,0.00002634419,0.001052862],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002395685,"threshold_uncertainty_score":0.01266974,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04474451519208964,"score_gpt":0.3582726027370102,"score_spread":0.3135280875449205,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}