{"id":"W2907316332","doi":"10.1182/blood-2018-99-110483","title":"Fostamatinib, a Spleen Tyrosine Kinase Inhibitor, for the Treatment of Warm Antibody Autoimmune Hemolytic Anemia: Initial Results of the Multicenter, Open-Label Extension Period of the Soar Phase 2 Study","year":2018,"lang":"en","type":"article","venue":"Blood","topic":"Blood groups and transfusion","field":"Medicine","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University","funders":"","keywords":"Autoimmune hemolytic anemia; Syk; Medicine; Anemia; Antibody; Internal medicine; Immunology; Gastroenterology; Pharmacology; Tyrosine kinase; Receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004202803,0.0002376288,0.0005755075,0.00004619302,0.0002706033,0.00001619399,0.0003885879,0.0000923305,0.00001222122],"category_scores_gemma":[0.0001742433,0.0001062326,0.0001836497,0.0002945874,0.0003617406,0.00005862687,0.0001741847,0.0001224346,9.143741e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002093504,"about_ca_system_score_gemma":0.0001425332,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005721753,"about_ca_topic_score_gemma":0.00009699013,"domain_scores_codex":[0.9981352,0.0001211873,0.0007939807,0.0003221941,0.0003932923,0.0002341596],"domain_scores_gemma":[0.9978144,0.0001924526,0.0004175162,0.001145929,0.0003797237,0.00005002247],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.01132734,0.101946,0.003839863,0.0003083237,0.0006164239,0.00002336343,0.01342149,0.000001121528,0.8562699,0.0000290863,0.0001215809,0.01209553],"study_design_scores_gemma":[0.1936259,0.02343181,0.0274196,0.0007545173,0.003270408,0.0000379129,0.001793066,0.0005845121,0.748466,0.00001273288,0.000464679,0.0001388783],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9921351,0.0008465076,0.0000220674,0.001032114,0.000378634,0.005206492,0.000285989,0.00001312031,0.00007997813],"genre_scores_gemma":[0.9991236,0.00008167281,0.0003278606,0.00006713651,0.0001728118,0.00006639887,0.00002809518,0.00003187323,0.0001005607],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1822986,"threshold_uncertainty_score":0.4332042,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04474451519208964,"score_gpt":0.3582726027370102,"score_spread":0.3135280875449205,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}