{"id":"W2907428629","doi":"10.1016/j.isci.2018.12.031","title":"Genome-wide Screen for Culture Adaptation and Tumorigenicity-Related Genes in Human Pluripotent Stem Cells","year":2019,"lang":"en","type":"article","venue":"iScience","topic":"Pluripotent Stem Cells Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":12,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Azrieli Foundation; Israel Academy of Sciences and Humanities; United States-Israel Binational Science Foundation; Rosetrees Trust","keywords":"Induced pluripotent stem cell; Biology; Gene; Regenerative medicine; PI3K/AKT/mTOR pathway; Adaptation (eye); Phenotype; Genome editing; Stem cell; Genome; Genetics; Cell biology; Computational biology; Embryonic stem cell; Signal transduction; Neuroscience","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002826443,0.0003178338,0.0003726924,0.0006617489,0.0002277335,0.0002503812,0.0001968343,0.0002971567,0.001033733],"category_scores_gemma":[0.00026082,0.000134568,0.0004055276,0.0006450659,0.000115729,0.00007357415,0.0002100963,0.0003991844,0.0002366445],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001542949,"about_ca_system_score_gemma":0.0003081224,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006005226,"about_ca_topic_score_gemma":0.001477433,"domain_scores_codex":[0.9998134,0.00002937122,0.00001727772,0.00005212908,0.00006488391,0.00002307034],"domain_scores_gemma":[0.9998198,0.00007054778,0.00004375468,0.00001640539,0.00002507459,0.00002449712],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007012409,0.00002677581,0.001688395,0.00006045623,0.00002733442,0.0001552056,0.00001174621,0.0001346923,0.9953851,0.00004346164,0.00008587565,0.002310819],"study_design_scores_gemma":[0.00005478772,0.0008512651,0.1418404,0.00002080138,0.0005407091,0.001814117,0.00009207834,0.002360817,0.8404956,0.0001492538,0.01175456,0.0000255516],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9675435,0.004134399,0.01451935,0.0001887214,0.00003632373,0.00022271,0.01091109,0.0003037626,0.002140093],"genre_scores_gemma":[0.953142,0.002454033,0.01331981,0.0003037462,0.00001852494,0.0002268024,0.02723006,0.00008938232,0.003215549],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001033733,"threshold_uncertainty_score":0.003458142,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01791113503998112,"score_gpt":0.2586025969350923,"score_spread":0.2406914618951112,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}