{"id":"W2907443362","doi":"10.1182/blood-2018-99-119302","title":"Results from Ongoing Phase 1/2 Clinical Trial of Tagraxofusp (SL-401) in Patients with Relapsed/Refractory Chronic Myelomonocytic Leukemia (CMML)","year":2018,"lang":"en","type":"article","venue":"Blood","topic":"Chronic Lymphocytic Leukemia Research","field":"Medicine","cited_by":15,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; University Health Network","funders":"","keywords":"Medicine; Chronic myelomonocytic leukemia; Internal medicine; Refractory (planetary science); Interleukin-3 receptor; Regimen; Oncology; Decitabine; Azacitidine; Gastroenterology; Leukemia; Myelodysplastic syndromes; Bone marrow; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002147423,0.001127517,0.001192673,0.0002558883,0.0003599711,0.000753327,0.0005586162,0.001166154,0.0038643],"category_scores_gemma":[0.0009007796,0.0002853478,0.00102605,0.0002391778,0.000541206,0.0007600855,0.0002796089,0.002548194,0.0009015168],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007351955,"about_ca_system_score_gemma":0.001071599,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000574356,"about_ca_topic_score_gemma":0.001913636,"domain_scores_codex":[0.9996523,0.0001524504,0.00002366971,0.00005451012,0.00004226694,0.00007470892],"domain_scores_gemma":[0.9993767,0.0001109668,0.0001359503,0.00004800657,0.00005486922,0.0002734314],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.4814588,0.07123897,0.01782799,0.00242786,0.002584956,0.0006276025,0.000598179,0.003750781,0.09009416,0.00060371,0.01563253,0.3131544],"study_design_scores_gemma":[0.3824915,0.5695772,0.0275062,0.0001524913,0.0009499554,0.0007645885,0.0001174793,0.001362087,0.006566821,0.000594974,0.009870119,0.0000464558],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9827868,0.005367217,0.0008432166,0.001482524,0.000149832,0.003396821,0.00305594,0.0001718048,0.002745968],"genre_scores_gemma":[0.9751437,0.003627898,0.002560397,0.002290779,0.0001988966,0.004318708,0.008089283,0.00003538093,0.003734939],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0038643,"threshold_uncertainty_score":0.01292735,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0379540287808474,"score_gpt":0.3492766603695263,"score_spread":0.3113226315886788,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}