{"id":"W2907470518","doi":"10.1016/j.stem.2018.12.007","title":"The Making of a Leukemic Stem Cell: A Novel Role for IKZF2 in AML Stemness and Differentiation","year":2019,"lang":"en","type":"letter","venue":"Cell stem cell","topic":"Acute Myeloid Leukemia Research","field":"Medicine","cited_by":4,"is_retracted":false,"has_abstract":false,"ca_institutions":"Princess Margaret Cancer Centre","funders":"","keywords":"Stem cell; Myeloid leukemia; Biology; Leukemia; Myeloid; Cancer research; Chromatin; Cellular differentiation; Haematopoiesis; Immunology; Cell biology; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0006743332,0.0005611911,0.001089856,0.0003942886,0.0001323761,0.00009945306,0.0005718671,0.00104123,0.00001927972],"category_scores_gemma":[0.000009121403,0.0004190606,0.0002649673,0.0002872327,0.0001317419,0.00008378828,0.0003092536,0.001985212,0.00003992],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0009617224,"about_ca_system_score_gemma":0.0006480586,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00008544536,"about_ca_topic_score_gemma":0.00002284311,"domain_scores_codex":[0.9963653,0.0001852895,0.0009081785,0.0008456469,0.0007792083,0.0009163447],"domain_scores_gemma":[0.996877,0.001084466,0.000701208,0.001026296,0.0002488433,0.0000622429],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.001756009,0.0005279568,0.004833394,0.04559753,0.0002915538,0.0001804414,0.005135924,0.00007293877,0.2828338,0.00002225358,0.6462045,0.01254372],"study_design_scores_gemma":[0.021383,0.001133585,0.001693719,0.002652105,0.0008413046,0.00006588154,0.004558276,0.01797058,0.09987484,0.00003883772,0.8482684,0.001519434],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8938164,0.01495022,0.003072108,0.05057384,0.001871902,0.01607524,0.0006119037,0.0001722397,0.01885611],"genre_scores_gemma":[0.8527214,0.0005080983,0.0002892471,0.02468769,0.001264359,0.0005426538,0.0004688132,0.000415708,0.119102],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2020639,"threshold_uncertainty_score":0.9998261,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0234308865697399,"score_gpt":0.2594904279318855,"score_spread":0.2360595413621456,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}