{"id":"W2907470518","doi":"10.1016/j.stem.2018.12.007","title":"The Making of a Leukemic Stem Cell: A Novel Role for IKZF2 in AML Stemness and Differentiation","year":2019,"lang":"en","type":"letter","venue":"Cell stem cell","topic":"Acute Myeloid Leukemia Research","field":"Medicine","cited_by":4,"is_retracted":false,"has_abstract":false,"ca_institutions":"Princess Margaret Cancer Centre","funders":"","keywords":"Stem cell; Myeloid leukemia; Biology; Leukemia; Myeloid; Cancer research; Chromatin; Cellular differentiation; Haematopoiesis; Immunology; Cell biology; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001519128,0.0004614495,0.0007421174,0.0003797855,0.002080278,0.0022023,0.0008584359,0.02531101,0.003188967],"category_scores_gemma":[0.01014802,0.0003381598,0.0006433321,0.000255567,0.002508589,0.002863382,0.001096277,0.02171693,0.002004591],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.002704558,"about_ca_system_score_gemma":0.001546204,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001239567,"about_ca_topic_score_gemma":0.001850737,"domain_scores_codex":[0.9987735,0.0004361855,0.000142374,0.000164652,0.0002945468,0.0001886438],"domain_scores_gemma":[0.997093,0.001799638,0.0002020686,0.000136775,0.0003402707,0.0004282214],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002865611,0.00008708455,0.001804373,0.0001410921,0.00003944165,0.03025319,0.0005545383,0.0002408904,0.002132087,0.02073058,0.9071959,0.03653422],"study_design_scores_gemma":[0.0002568337,0.0001552543,0.001209598,0.0002110459,0.00004867541,0.0299228,0.0009108802,0.001254538,0.001402688,0.06250153,0.9020433,0.00008284089],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"commentary","genre_gemma":"empirical","genre_scores_codex":[0.001377597,0.00205545,0.0002266311,0.9805249,0.01344477,0.000007105512,0.00002035066,0.00001632096,0.0023268],"genre_scores_gemma":[0.0443764,0.004445671,0.001179886,0.8295274,0.1074431,0.00005119814,0.00003911017,0.00003252307,0.01290457],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.02531101,"threshold_uncertainty_score":0.01962304,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0234308865697399,"score_gpt":0.2594904279318855,"score_spread":0.2360595413621456,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}