{"id":"W2907490175","doi":"10.1371/journal.pmed.1002724","title":"The influence of obesity-related factors in the etiology of renal cell carcinoma—A mendelian randomization study","year":2019,"lang":"en","type":"article","venue":"PLoS Medicine","topic":"Renal cell carcinoma treatment","field":"Medicine","cited_by":87,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Jewish General Hospital; McGill University and Génome Québec Innovation Centre","funders":"National Cancer Institute; World Cancer Research Fund; Medical Research Council; Canadian Institutes of Health Research; University of Bristol; World Cancer Research Fund International; National Institutes of Health; Cancer Research UK; AstraZeneca; University Hospitals Bristol NHS Foundation Trust; Wellcome Trust; National Institute for Health and Care Research; Duncan Family Institute for Cancer Prevention and Risk Assessment; World Health Organization; University of Texas MD Anderson Cancer Center; Pfizer","keywords":"Mendelian randomization; Medicine; Internal medicine; Odds ratio; Renal cell carcinoma; Body mass index; Blood pressure; Obesity; Confidence interval; Genome-wide association study; Oncology; Confounding; Type 2 diabetes; Risk factor; Diabetes mellitus; Endocrinology; Single-nucleotide polymorphism; Genetics; Biology; Genotype; Genetic variants","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.01855271,0.0007948842,0.0008639741,0.000857689,0.00052182,0.0007807238,0.0007790969,0.0008986442,0.001266484],"category_scores_gemma":[0.02885497,0.000460384,0.00168342,0.0009968883,0.0007276789,0.0004488486,0.000548168,0.0005948464,0.0001443306],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004240986,"about_ca_system_score_gemma":0.0006052378,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002129429,"about_ca_topic_score_gemma":0.001260748,"domain_scores_codex":[0.9803741,0.01488988,0.0007930717,0.002394677,0.001253786,0.0002944561],"domain_scores_gemma":[0.9857949,0.007800428,0.002594577,0.003129026,0.0004167783,0.0002641411],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.02122397,0.0006784688,0.8922934,0.000468403,0.01379668,0.002620897,0.0007847756,0.003322464,0.008398146,0.01107062,0.001836117,0.04350598],"study_design_scores_gemma":[0.0067666,0.00788658,0.8369226,0.0002785578,0.01911996,0.01206524,0.0004066644,0.08279108,0.003983901,0.02117697,0.008356154,0.0002457566],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.953591,0.00355199,0.04001489,0.0006465424,0.0001480693,0.0003390859,0.000375556,0.0001480236,0.001184719],"genre_scores_gemma":[0.9900564,0.0002788535,0.009074261,0.0001631642,0.00004527346,0.0001201258,0.0001057348,0.00001990412,0.0001362265],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01855271,"threshold_uncertainty_score":0.09811723,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0172508609271009,"score_gpt":0.2477743781513598,"score_spread":0.2305235172242589,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}