{"id":"W2907496349","doi":"10.1016/j.cell.2018.11.030","title":"Late Endosomes Act as mRNA Translation Platforms and Sustain Mitochondria in Axons","year":2019,"lang":"en","type":"article","venue":"Cell","topic":"Cellular transport and secretion","field":"Biochemistry, Genetics and Molecular Biology","cited_by":454,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"European Research Council; Natural Sciences and Engineering Research Council of Canada; Gates Cambridge Trust; Biotechnology and Biological Sciences Research Council; Studienstiftung des Deutschen Volkes; EMBO; Nederlandse Organisatie voor Wetenschappelijk Onderzoek; Wellcome Trust","keywords":"Endosome; Biology; Cell biology; Translation (biology); Axon; RNA; Mitochondrion; Axoplasmic transport; Messenger RNA; Biochemistry; Gene","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000154112,0.0003366138,0.0002717701,0.0003865298,0.0006019719,0.0007255314,0.000233547,0.0004797735,0.00087805],"category_scores_gemma":[0.0001433945,0.0002276792,0.0002407014,0.000132847,0.0003481838,0.0005815759,0.0005825846,0.0004165121,0.000845961],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006571527,"about_ca_system_score_gemma":0.0003617964,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001009481,"about_ca_topic_score_gemma":0.00209671,"domain_scores_codex":[0.9998935,0.00001302304,0.000006984519,0.00002674918,0.00003025347,0.0000293859],"domain_scores_gemma":[0.99986,0.00001338759,0.00003656769,0.00001333852,0.00003000063,0.00004655495],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007069019,0.000005378869,0.0004656458,0.00002561697,0.000003739297,0.0001747166,0.00003738044,0.00005234051,0.9974756,0.0005370213,0.00004135294,0.001110687],"study_design_scores_gemma":[0.00001794861,0.0001440188,0.02218413,0.00002142091,0.00002534536,0.001053708,0.0001661157,0.002249348,0.9674763,0.0006173872,0.00602879,0.00001534356],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9835047,0.003453746,0.00972133,0.0001483469,0.00004272285,0.00001511718,0.0001380745,0.0002446448,0.002731395],"genre_scores_gemma":[0.9895105,0.001002126,0.004406728,0.00003213239,0.00001424833,0.00001277679,0.0001415017,0.0000517878,0.004828231],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001009481,"threshold_uncertainty_score":0.004768014,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005980619122213228,"score_gpt":0.2066799450057878,"score_spread":0.2006993258835745,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}