{"id":"W2907539128","doi":"10.1038/s41467-018-07884-6","title":"PRMT5 is essential for B cell development and germinal center dynamics","year":2018,"lang":"en","type":"article","venue":"Nature Communications","topic":"Cancer-related gene regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":87,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Université de Montréal; Université du Québec à Montréal; Jewish General Hospital; Collège de Maisonneuve; Hôpital Maisonneuve-Rosemont; Bombardier (Canada); McGill University Health Centre; Montreal Clinical Research Institute","funders":"Kenneth Rainin Foundation; Canadian Institutes of Health Research; Cancer Research Society","keywords":"Protein arginine methyltransferase 5; Germinal center; B cell; Cell biology; Biology; Cell; Cell growth; Immune system; Plasma cell; RNA splicing; Methyltransferase; RNA; Antibody; Immunology; Genetics; Methylation; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00006491789,0.00007550076,0.00005348717,0.00002737832,0.0002114412,0.00001719756,0.000246571,0.0002421838,0.000005443208],"category_scores_gemma":[0.00001453961,0.00007962387,0.00002971051,0.00005245749,0.0001064903,0.000002960488,0.0001938753,0.0001233937,0.000003511388],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002983104,"about_ca_system_score_gemma":0.00007584279,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000002102451,"about_ca_topic_score_gemma":0.0005143294,"domain_scores_codex":[0.9995549,0.00001856593,0.0001138577,0.0001569339,0.00005194805,0.0001038436],"domain_scores_gemma":[0.9991496,0.00001101934,0.00005714635,0.0005899735,0.0001590412,0.0000332881],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0006340856,0.001215277,0.01589167,0.000193846,0.0005512759,4.688925e-7,0.002950729,0.00001722353,0.6403559,0.008658669,0.1774957,0.1520351],"study_design_scores_gemma":[0.0005582041,0.00007513665,0.002763034,0.00001089529,0.00002383451,0.000007512506,0.00003860027,0.001873294,0.2142231,0.00005595193,0.780216,0.0001544746],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9744624,0.006643229,0.009589655,0.004026109,0.0004177781,0.0006401574,0.000139237,0.00002689621,0.004054527],"genre_scores_gemma":[0.9782555,0.0001791738,0.01955215,0.0002484866,0.0001588836,0.00003590652,0.0007717922,0.00001347052,0.0007846532],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.6027202,"threshold_uncertainty_score":0.3246967,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007608765189567723,"score_gpt":0.2866119741092873,"score_spread":0.2790032089197196,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}