{"id":"W2907539128","doi":"10.1038/s41467-018-07884-6","title":"PRMT5 is essential for B cell development and germinal center dynamics","year":2018,"lang":"en","type":"article","venue":"Nature Communications","topic":"Cancer-related gene regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":87,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Université de Montréal; Université du Québec à Montréal; Jewish General Hospital; Collège de Maisonneuve; Hôpital Maisonneuve-Rosemont; Bombardier (Canada); McGill University Health Centre; Montreal Clinical Research Institute","funders":"Kenneth Rainin Foundation; Canadian Institutes of Health Research; Cancer Research Society","keywords":"Protein arginine methyltransferase 5; Germinal center; B cell; Cell biology; Biology; Cell; Cell growth; Immune system; Plasma cell; RNA splicing; Methyltransferase; RNA; Antibody; Immunology; Genetics; Methylation; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001541134,0.0003985057,0.0002704469,0.0002817615,0.0004409794,0.0006764067,0.0003949806,0.0006082373,0.00197804],"category_scores_gemma":[0.00034063,0.0002508445,0.0004264631,0.0002309841,0.0002918293,0.0003701139,0.0005268177,0.0005460651,0.00153543],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005121134,"about_ca_system_score_gemma":0.0003357193,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001312691,"about_ca_topic_score_gemma":0.001482372,"domain_scores_codex":[0.9997464,0.00002113172,0.0000197179,0.00008476146,0.00008403001,0.00004408431],"domain_scores_gemma":[0.9997502,0.00002229859,0.00009034116,0.00003247812,0.00002903171,0.00007556988],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001506922,0.00001167016,0.001362487,0.0001093164,0.00001167649,0.0002237585,0.00003115671,0.0001898041,0.9908309,0.0006317534,0.0003066725,0.006140128],"study_design_scores_gemma":[0.00002980202,0.0001579332,0.02835475,0.0000358937,0.0000471445,0.001336205,0.00005149883,0.002825782,0.9390212,0.0005754182,0.02754711,0.00001725738],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9543787,0.01042649,0.0232753,0.0004534807,0.0001663188,0.00003966137,0.002961378,0.001657203,0.006641438],"genre_scores_gemma":[0.9898235,0.0008738823,0.003546129,0.0001001056,0.00001781701,0.00001245448,0.002101801,0.0001220215,0.003402296],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00197804,"threshold_uncertainty_score":0.006617188,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007608765189567723,"score_gpt":0.2866119741092873,"score_spread":0.2790032089197196,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}